Thyroid carcinoma surgery in children and adolescents - 15 years experience surgery of pediatric thyroid carcinoma
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24794415
DOI
10.1016/j.ijporl.2014.03.005
PII: S0165-5876(14)00137-2
Knihovny.cz E-zdroje
- Klíčová slova
- Adolescent, Carcinoma, Child, Neck dissection, Thyroidectomy,
- MeSH
- adjuvantní radioterapie MeSH
- dítě MeSH
- hypokalcemie epidemiologie MeSH
- karcinom genetika mortalita patologie chirurgie MeSH
- krční disekce MeSH
- lidé MeSH
- lymfatické metastázy MeSH
- mladiství MeSH
- mutace MeSH
- nádory plic sekundární MeSH
- nádory štítné žlázy genetika mortalita patologie chirurgie MeSH
- pooperační komplikace epidemiologie MeSH
- protoonkogenní proteiny c-ret genetika MeSH
- radioizotopy jodu terapeutické užití MeSH
- retrospektivní studie MeSH
- tyreoidektomie statistika a číselné údaje MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- protoonkogenní proteiny c-ret MeSH
- radioizotopy jodu MeSH
- RET protein, human MeSH Prohlížeč
OBJECTIVES: The purpose of this study is to evaluate the characteristics of thyroid gland surgery focusing on malignancies at the pediatric age with the main concern on treatment results and complications in extensive primary treatment. METHODS: The records of all patients 18 years and younger with surgically treated thyroid diseases in the Prague Hospital, Motol, between 1991 and 2006 were retrospectively reviewed. RESULTS: Thyroid surgery was performed on 148 pediatric patients (including 56 carcinomas). The youngest patient involved in the study was seven years old, the oldest patient 18 years old (mean 13.7 years). Most frequent histological cancer type was PTC (42 cases, 75%). Follicular cancer was diagnosed in five cases (8.9%) and medullar cancer in nine cases (16.1%). A prophylactic thyroidectomy was performed in three cases (5.4%) without clinical signs of thyroid tumor with diagnosed RET gene mutation. CONCLUSIONS: We consider total thyroidectomy with subsequent radioiodine ablation and TSH suppression as the basic approach in the treatment protocol of pediatric WDTC. The observed 100% recurrence-free and overall survival together with a low incidence of postoperative complications strongly supports the idea of a total thyroidectomy with selective neck dissection in the treatment of metastases of WDTC and MTC.
Department of Nuclear Medicine Charles University Motol Prague Czech Republic
Institute of Endocrinology Charles University Motol Prague Czech Republic
Citace poskytuje Crossref.org
Endoscopic/external approaches in otorhinolaryngology and head and neck surgery
