Thyroid carcinoma surgery in children and adolescents - 15 years experience surgery of pediatric thyroid carcinoma
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24794415
DOI
10.1016/j.ijporl.2014.03.005
PII: S0165-5876(14)00137-2
Knihovny.cz E-resources
- Keywords
- Adolescent, Carcinoma, Child, Neck dissection, Thyroidectomy,
- MeSH
- Radiotherapy, Adjuvant MeSH
- Child MeSH
- Hypocalcemia epidemiology MeSH
- Carcinoma genetics mortality pathology surgery MeSH
- Neck Dissection MeSH
- Humans MeSH
- Lymphatic Metastasis MeSH
- Adolescent MeSH
- Mutation MeSH
- Lung Neoplasms secondary MeSH
- Thyroid Neoplasms genetics mortality pathology surgery MeSH
- Postoperative Complications epidemiology MeSH
- Proto-Oncogene Proteins c-ret genetics MeSH
- Iodine Radioisotopes therapeutic use MeSH
- Retrospective Studies MeSH
- Thyroidectomy statistics & numerical data MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Proto-Oncogene Proteins c-ret MeSH
- Iodine Radioisotopes MeSH
- RET protein, human MeSH Browser
OBJECTIVES: The purpose of this study is to evaluate the characteristics of thyroid gland surgery focusing on malignancies at the pediatric age with the main concern on treatment results and complications in extensive primary treatment. METHODS: The records of all patients 18 years and younger with surgically treated thyroid diseases in the Prague Hospital, Motol, between 1991 and 2006 were retrospectively reviewed. RESULTS: Thyroid surgery was performed on 148 pediatric patients (including 56 carcinomas). The youngest patient involved in the study was seven years old, the oldest patient 18 years old (mean 13.7 years). Most frequent histological cancer type was PTC (42 cases, 75%). Follicular cancer was diagnosed in five cases (8.9%) and medullar cancer in nine cases (16.1%). A prophylactic thyroidectomy was performed in three cases (5.4%) without clinical signs of thyroid tumor with diagnosed RET gene mutation. CONCLUSIONS: We consider total thyroidectomy with subsequent radioiodine ablation and TSH suppression as the basic approach in the treatment protocol of pediatric WDTC. The observed 100% recurrence-free and overall survival together with a low incidence of postoperative complications strongly supports the idea of a total thyroidectomy with selective neck dissection in the treatment of metastases of WDTC and MTC.
Department of Nuclear Medicine Charles University Motol Prague Czech Republic
Institute of Endocrinology Charles University Motol Prague Czech Republic
References provided by Crossref.org
Endoscopic/external approaches in otorhinolaryngology and head and neck surgery
