Determination of impurities and counterions of pharmaceuticals by capillary electromigration methods
Language English Country Germany Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't, Review
- Keywords
- Capillary electrophoresis, Chiral impurities, Drug counterions, Drug impurities, Pharmaceutical analysis,
- MeSH
- Electrophoresis, Capillary methods MeSH
- Ions analysis MeSH
- Drug Contamination prevention & control MeSH
- Pharmaceutical Preparations analysis MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Ions MeSH
- Pharmaceutical Preparations MeSH
The review presents a survey of recent applications of high-performance capillary electromigration methods-capillary zone electrophoresis, nonaqueous capillary electrophoresis, capillary isotachophoresis, micellar electrokinetic chromatography, microemulsion electrokinetic chromatography and capillary electrochromatography-for the determination of impurities of pharmaceuticals, including chiral impurities, for the period 2007-2013. In addition, due to the missing evaluation of the determination of counterions of pharmaceuticals by capillary electromigration methods in the last 20 years, the publications dealing with this topic since 1995 are included in this review. General aspects of both these types of applications of capillary electromigration methods in pharmaceutical analysis are discussed, and detailed experimental conditions used for determination of various chemical impurities and counterions of many particular drugs are described.
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