Innovative surface modification of Ti-6Al-4V alloy with a positive effect on osteoblast proliferation and fatigue performance
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24863238
DOI
10.1016/j.msec.2014.03.024
PII: S0928-4931(14)00150-7
Knihovny.cz E-zdroje
- Klíčová slova
- Acid etching, Mechanical properties, Osteoblast viability, Osteogenic differentiation, Shot peening, Surface roughness,
- MeSH
- biokompatibilní materiály chemie MeSH
- buněčná adheze účinky léků MeSH
- buněčná diferenciace účinky léků MeSH
- fluorescenční protilátková technika MeSH
- fotoelektronová spektroskopie MeSH
- lidé MeSH
- mikroskopie elektronová rastrovací MeSH
- nádorové buněčné linie MeSH
- osteoblasty cytologie účinky léků MeSH
- povrchové vlastnosti MeSH
- proliferace buněk účinky léků MeSH
- protézy a implantáty MeSH
- slitiny MeSH
- titan chemie farmakologie MeSH
- viabilita buněk účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biokompatibilní materiály MeSH
- slitiny MeSH
- titan MeSH
- titanium alloy (TiAl6V4) MeSH Prohlížeč
A novel approach of surface treatment of orthopaedic implants combining electric discharge machining (EDM), chemical milling (etching) and shot peening is presented in this study. Each of the three techniques have been used or proposed to be used as a favourable surface treatment of biomedical titanium alloys. But to our knowledge, the three techniques have not yet been used in combination. Surface morphology and chemistry were studied by scanning electron microscopy and X-ray photoelectron spectroscopy, respectively. Fatigue life of the material was determined and finally several in-vitro biocompatibility tests have been performed. EDM and subsequent chemical milling leads to a significant improvement of osteoblast proliferation and viability thanks to favourable surface morphology and increased oxygen content on the surface. Subsequent shot-peening significantly improves the fatigue endurance of the material. Material after proposed combined surface treatment possesses favourable mechanical properties and enhanced osteoblast proliferation. EDM treatment and EDM with shot peening also supported early osteogenic cell differentiation, manifested by a higher expression of collagen type I. The combined surface treatment is therefore promising for a range of applications in orthopaedics.
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