Different effects of lobeline on neuronal and muscle nicotinic receptors
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24929055
DOI
10.1016/j.ejphar.2014.05.057
PII: S0014-2999(14)00439-7
Knihovny.cz E-zdroje
- Klíčová slova
- Embryonic muscle nicotinic receptor, Lobeline, Neuronal nicotinic receptor alpha3beta4,
- MeSH
- Cercopithecus aethiops MeSH
- COS buňky MeSH
- krysa rodu Rattus MeSH
- lidé MeSH
- lobelin farmakologie MeSH
- neurony účinky léků metabolismus MeSH
- nikotinové receptory metabolismus MeSH
- nikotinoví agonisté farmakologie MeSH
- orgánová specificita MeSH
- svaly účinky léků metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- lobelin MeSH
- nicotinic receptor alpha3beta2 MeSH Prohlížeč
- nikotinové receptory MeSH
- nikotinoví agonisté MeSH
Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal α3β4 receptors expressed in COS cells and muscle embryonic αβγδ receptors naturally expressed in TE671 cells was studied using a patch-clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo-noncompetitive manner. The responses of rat neuronal α3β4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to "competitive potentiation". This potentiation turned into voltage-dependent inhibition for α3β4 receptors was activated by a high concentration of acetylcholine.
Citace poskytuje Crossref.org
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