Superparamagnetic iron oxide-enhanced magnetic resonance for imaging cardiac inflammation. A minireview
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24993740
DOI
10.5507/bp.2014.030
Knihovny.cz E-resources
- Keywords
- inflammation, magnetic resonance imaging, superparamagnetic iron oxide,
- MeSH
- Dextrans pharmacokinetics MeSH
- Contrast Media pharmacokinetics MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Magnetite Nanoparticles MeSH
- Myocardium pathology MeSH
- Graft Rejection diagnostic imaging metabolism MeSH
- Heart Transplantation * MeSH
- Particle Size MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Dextrans MeSH
- ferumoxides MeSH Browser
- Contrast Media MeSH
- Magnetite Nanoparticles MeSH
BACKGROUND: Advances in nanotechnology have lead to the development of a novel contrast media for Magnetic Resonance Imaging (MRI) - the superparamagnetic iron oxide nanoparticle (SPIO). SPIO nanoparticles are used to image inflammation on the cellular level in various settings. This review covers the physicochemical characteristics of SPIO particles as well as relevant animal and clinical studies and discusses the potential of SPIO particles to image cardiac inflammation including cardiac graft rejection. METHODS: We searched the scientific biomedical databases Medline/PubMed, BioMedCentral, Google Scholar, Ovid and, ProQuest from to 2000 to 2013 for publications relevant to the topic. CONCLUSIONS: SPIO nanoparticles due to their unique properties could become a useful tool in imaging cardiac inflammation. However, the task is to find a suitable particle size and coating with corresponding pharmacokinetics, establish the right dose and MRI scan timing for individual applications.
Department of Cardiovascular Diseases ICRC St Anne's University Hospital in Brno Czech Republic
Department of Imaging Methods ICRC St Anne's University Hospital in Brno
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