The miR-29 family in hematological malignancies
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
25004911
DOI
10.5507/bp.2014.037
Knihovny.cz E-resources
- Keywords
- circulating miRNA, hematological malignancy, miR-29 family, microRNA,
- MeSH
- Apoptosis genetics MeSH
- Extracellular Matrix genetics MeSH
- Hematologic Neoplasms genetics MeSH
- Humans MeSH
- MicroRNAs genetics physiology MeSH
- Cell Transformation, Neoplastic genetics MeSH
- Cell Proliferation genetics MeSH
- Cellular Senescence genetics MeSH
- Genes, Tumor Suppressor physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- MicroRNAs MeSH
- MIRN29a microRNA, human MeSH Browser
BACKGROUND: MicroRNAs are short non-coding regulators of gene expression. The human miR-29 family consists of three members: miR-29a, miR-29b and miR-29c. Members of this family were found to be aberrantly expressed in various types of tumors, including hematological malignancies. This family was described to have both oncogenic and tumor suppressor features influencing various pathological processes, such as tumor growth and apoptosis. This review summarizes current knowledge about the miR-29 family in selected hematological malignancies. CONCLUSION: Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. Nevertheless, the level of current evidence is not sufficient, and data remain inconclusive.
References provided by Crossref.org
MicroRNAs in urine are not biomarkers of multiple myeloma
