The miR-29 family in hematological malignancies
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
25004911
DOI
10.5507/bp.2014.037
Knihovny.cz E-zdroje
- Klíčová slova
- circulating miRNA, hematological malignancy, miR-29 family, microRNA,
- MeSH
- apoptóza genetika MeSH
- extracelulární matrix genetika MeSH
- hematologické nádory genetika MeSH
- lidé MeSH
- mikro RNA genetika fyziologie MeSH
- nádorová transformace buněk genetika MeSH
- proliferace buněk genetika MeSH
- stárnutí buněk genetika MeSH
- tumor supresorové geny fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- mikro RNA MeSH
- MIRN29a microRNA, human MeSH Prohlížeč
BACKGROUND: MicroRNAs are short non-coding regulators of gene expression. The human miR-29 family consists of three members: miR-29a, miR-29b and miR-29c. Members of this family were found to be aberrantly expressed in various types of tumors, including hematological malignancies. This family was described to have both oncogenic and tumor suppressor features influencing various pathological processes, such as tumor growth and apoptosis. This review summarizes current knowledge about the miR-29 family in selected hematological malignancies. CONCLUSION: Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. Nevertheless, the level of current evidence is not sufficient, and data remain inconclusive.
Citace poskytuje Crossref.org
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