Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

In vitro antibacterial and antifungal activity of salicylanilide benzoates

Martin Krátký, Jarmila Vinšová, Vladimír Buchta

. 2012 ; 2012 () : 290628.

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc13000753

Grantová podpora
NS10367 MZ0 CEP - Centrální evidence projektů

The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl)phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations ≥ 0.98 μmol/L including methicillin-resistant Staphylococcus aureus strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)phenyl benzoate. The antifungal activity is significantly lower.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13000753
003      
CZ-PrNML
005      
20140905125606.0
007      
ta
008      
130108s2012 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1100/2012/290628 $2 doi
035    __
$a (PubMed)22666101
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Krátký, Martin $u Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic
245    10
$a In vitro antibacterial and antifungal activity of salicylanilide benzoates / $c Martin Krátký, Jarmila Vinšová, Vladimír Buchta
520    9_
$a The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl)phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations ≥ 0.98 μmol/L including methicillin-resistant Staphylococcus aureus strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)phenyl benzoate. The antifungal activity is significantly lower.
650    _2
$a antibakteriální látky $x farmakologie $7 D000900
650    _2
$a antifungální látky $x farmakologie $7 D000935
650    _2
$a benzoáty $x farmakologie $7 D001565
650    _2
$a magnetická rezonanční spektroskopie $7 D009682
650    _2
$a mikrobiální testy citlivosti $7 D008826
650    _2
$a salicylanilidy $x farmakologie $7 D012458
650    _2
$a spektrofotometrie infračervená $7 D013055
650    _2
$a techniky in vitro $7 D066298
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Vinšová, Jarmila $u Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic
700    1_
$a Buchta, Vladimír $u Department of Clinical Microbiology, Faculty of Medicine and University Hospital, Charles University, Hradec Králové, the Czech Republic; Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Hradec Králové, the Czech Republic
773    0_
$w MED00181094 $t TheScientificWorldJournal $x 1537-744X $g Roč. 2012(2012), s. 290628
856    41
$u https://pubmed.ncbi.nlm.nih.gov/22666101 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20130108 $b ABA008
991    __
$a 20140905130002 $b ABA008
999    __
$a ok $b bmc $g 963535 $s 798917
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 2012 $d 290628 $i 1537-744X $m TheScientificWorldJournal $n ScientificWorldJournal $x MED00181094
GRA    __
$a NS10367 $p MZ0
LZP    __
$a Pubmed-20130108

Najít záznam

Citační ukazatele

Možnosti archivace