DNA damage in Wistar rats exposed to dithiocarbamate pesticide mancozeb
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
25152054
DOI
10.14712/fb2014060040202
PII: file/5732/fb2014a0024.pdf
Knihovny.cz E-resources
- MeSH
- Ditiocarb toxicity MeSH
- Erythrocytes drug effects metabolism MeSH
- Maneb toxicity MeSH
- Micronucleus Tests MeSH
- Micronuclei, Chromosome-Defective drug effects MeSH
- Erythrocyte Count MeSH
- DNA Damage * MeSH
- Rats, Wistar MeSH
- Zineb toxicity MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Ditiocarb MeSH
- mancozeb MeSH Browser
- Maneb MeSH
- Zineb MeSH
Pesticides are used in large amounts in agriculture and the evaluation of their toxic effects is of major concern to public and environmental health. The aim of the present study was to investigate the genotoxic potential of a commercial formulation of the fungicide mancozeb by the micronucleus test in bone marrow and the comet assay in total blood of Wistar rats. Adult male Wistar rats were treated with a solution of mancozeb at a concentration of 40 mg/kg/day, administered intraperitoneally for 18 consecutive days, and compared to a control group. The results indicate that mancozeb induced significantly higher DNA damage as detected by the comet assay and increased the frequency of micronuclei. The results show that mancozeb is genotoxic and may adversely affect the DNA integrity of exposed organisms.
Research Group on Environmental Quality Indicators Universidade Feevale Novo Hamburgo RS Brazil
Research Group on Human Health and Environment Universidade Feevale Novo Hamburgo RS Brazil
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