OBJECTIVE: To determine the association between the presence of oligohydramnios, determined as an amniotic fluid index ≤ 5 cm and the intra-amniotic inflammatory response, fetal inflammatory response and neonatal outcomes in actively managed preterm prelabor rupture of membranes (PPROM). METHODS: Women with singleton pregnancies complicated by PPROM at a gestational age of between 24+0 and 36+6 weeks were included in the study. Ultrasound assessments of the amniotic fluid index and evaluation of the amniotic fluid interleukin (IL)-6 levels were performed at admission. The umbilical cord blood IL-6 levels were evaluated after delivery. RESULTS: In total, 74 women were included. The women with oligohydramnios did not have different amniotic fluid IL-6 levels [with oligohydramnios: median 342 pg/mL, interquartile range (IQR) 110-1809 vs. without oligohydramnios: median 256 pg/mL, IQR 122-748; p = 0.71] or umbilical cord blood IL-6 levels (with oligohydramnios: median 8.2 pg/mL, IQR 3.8-146.9 vs. without oligohydramnios: median 5.9 pg/mL, IQR 2.1-27.9; p = 0.14) than those without oligohydramnios. No association between oligohydramnios and neonatal morbidity was found. A correlation between the amniotic fluid index and the interval from rupture of membranes to amniocentesis was observed (rho = -0.34; p = 0.003). CONCLUSION: The presence of oligohydramnios is not associated with an adverse outcome in actively managed PPROM in singleton pregnancies in the absence of other complications.

Department of Clinical Immunology and Allergy Charles University Prague Faculty of Medicine in Hradec Kralove University Hospital in Hradec Kralove Hradec Kralove Czech Republic

Department of Obstetrics and Gynecology Charles University Prague Faculty of Medicine in Hradec Kralove University Hospital in Hradec Kralove Hradec Kralove Czech Republic

Department of Obstetrics and Gynecology Charles University Prague Faculty of Medicine in Hradec Kralove University Hospital in Hradec Kralove Hradec Kralove Czech Republic; Biomedical Research Center University Hospital in Hradec Kralove Hradec Kralove Czech Republic

Department of Obstetrics and Gynecology Sahlgrenska University Hospital Gothenburg Sweden; Department of Public Health Oslo University Oslo Norway

Department of Obstetrics and Gynecology University Hospital in Pardubice Pardubice Czech Republic

Fingerland's Department of Pathology Charles University Prague Faculty of Medicine in Hradec Kralove University Hospital in Hradec Kralove Hradec Kralove Czech Republic

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