Higher doses of (+)MK-801 (dizocilpine) induced mortality and procedural but not cognitive deficits in delayed testing in the active place avoidance with reversal on the Carousel
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25317686
DOI
10.33549/physiolres.932832
PII: 932832
Knihovny.cz E-resources
- MeSH
- Excitatory Amino Acid Antagonists administration & dosage toxicity MeSH
- Dizocilpine Maleate administration & dosage toxicity MeSH
- Cognition Disorders chemically induced psychology MeSH
- Rats MeSH
- Rats, Long-Evans MeSH
- Psychomotor Performance drug effects MeSH
- Reversal Learning drug effects MeSH
- Psychoses, Substance-Induced psychology MeSH
- Avoidance Learning drug effects MeSH
- Escape Reaction drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Excitatory Amino Acid Antagonists MeSH
- Dizocilpine Maleate MeSH
Schizophrenia is a devastating disorder affecting 1 % of the world's population. An important role in the study of this disease is played by animal models. Since there is evidence that acute psychotic episodes can have consequences on later cognitive functioning, the present study has investigated the effects of a single systemic application of higher doses of (+)MK-801 (3 mg/kg and 5 mg/kg) to adult male Long-Evans rats from the Institute's breeding colony on delayed testing in the active place avoidance task with reversal on the Carousel (a rotating arena). Besides significant mortality due to the injections, a disruption of procedural functions in active place avoidance, after the dose 5 mg/kg was observed. It was concluded that Long-Evans rats from our breeding colony do not represent a suitable biomodel for studying the effects of single high-dose NMDA antagonists.
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