Urinary microRNAs as a new class of noninvasive biomarkers in oncology, nephrology, and cardiology
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Biomarkers urine MeSH
- Humans MeSH
- MicroRNAs genetics urine MeSH
- Neoplasms diagnosis genetics pathology urine MeSH
- Heart Diseases diagnosis genetics pathology urine MeSH
- RNA Stability MeSH
- Urologic Diseases diagnosis genetics pathology urine MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Biomarkers MeSH
- MicroRNAs MeSH
MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. In the last decade, number of evidences showing miRNAs contribution to the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes is constantly growing. Specific miRNA expression signatures have been identified in variety of human cancers as well as pathologies of cardiovascular and urinary systems. Our chapter focuses on the potential of urinary miRNAs to serve as biomarkers in uro-oncology, nephrology, and cardiology. We discuss in detail recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in medicine. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in urologic cancers, nephrology, and cardiology.
References provided by Crossref.org
MicroRNA-15a expression measured in urine samples as a potential biomarker of renal cell carcinoma
