Urinary microRNAs as a new class of noninvasive biomarkers in oncology, nephrology, and cardiology
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- biologické markery moč MeSH
- lidé MeSH
- mikro RNA genetika moč MeSH
- nádory diagnóza genetika patologie moč MeSH
- nemoci srdce diagnóza genetika patologie moč MeSH
- stabilita RNA MeSH
- urologické nemoci diagnóza genetika patologie moč MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- biologické markery MeSH
- mikro RNA MeSH
MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. In the last decade, number of evidences showing miRNAs contribution to the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes is constantly growing. Specific miRNA expression signatures have been identified in variety of human cancers as well as pathologies of cardiovascular and urinary systems. Our chapter focuses on the potential of urinary miRNAs to serve as biomarkers in uro-oncology, nephrology, and cardiology. We discuss in detail recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in medicine. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in urologic cancers, nephrology, and cardiology.
Citace poskytuje Crossref.org
MicroRNA-15a expression measured in urine samples as a potential biomarker of renal cell carcinoma
