Association of MTHFR genetic variants C677T and A1298C on predisposition to spontaneous abortion in Slavonic population
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25447701
DOI
10.1016/j.cca.2014.11.018
PII: S0009-8981(14)00523-3
Knihovny.cz E-zdroje
- Klíčová slova
- MTHFR, Polymorphism, Predisposition, Pregnancy loss, Spontaneous abortion,
- MeSH
- běloši genetika MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci MeSH
- genetická variace * MeSH
- heterozygot MeSH
- lidé MeSH
- methylentetrahydrofolátreduktasa (NADPH2) genetika MeSH
- polymorfismus genetický MeSH
- samovolný potrat genetika MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- methylentetrahydrofolátreduktasa (NADPH2) MeSH
- MTHFR protein, human MeSH Prohlížeč
AIM: Up to 20% of pregnancies end in the first trimester by spontaneous abortion but the cause of a large proportion remains unexplained. The aim of this study was to investigate the role of two common variants (rs1801133, C677T and rs1801131, A1298C) within the MTHFR gene in the genetic determination of spontaneous abortions. METHODS: DNA from 464 tissue samples of spontaneous abortions and population sample of adults (N=2,486) were genotyped for both MTHFR polymorphisms of interest. RESULTS: The frequencies of the MTHFR polymorphisms in tissues from spontaneous abortions did not differ from the population cohort. However, when combined, carriers of at least three rs1801133 and/or rs1801131 alleles were more common in the spontaneous abortions (61.4%) than in controls (55.4%) and this combination was associated with higher risk of abortion (OR 1.28; 95% CI 1.05-1.57; P=0.017). In contrast, carriers of at least three minor alleles (T677 and C1298) of these polymorphisms were very rare in both groups (0.8% and 0.9% respectively). CONCLUSIONS: Our study suggests that distinct combinations of the MTHFR polymorphisms could be associated with higher risk of spontaneous abortions in Caucasians.
Citace poskytuje Crossref.org
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