Analysis of preoperative serum levels of MMP1, -2, and -9 in patients with site-specific head and neck squamous cell cancer
Language English Country Greece Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25503184
PII: 34/12/7431
Knihovny.cz E-resources
- Keywords
- MMP1, MMP2, MMP9, head and neck squamous cell carcinoma, hypopharyngeal cancer, laryngeal, oropharyngeal, serum tumor marker,
- MeSH
- Alcoholism MeSH
- Squamous Cell Carcinoma of Head and Neck MeSH
- Immunohistochemistry MeSH
- Cyclin-Dependent Kinase Inhibitor p16 biosynthesis genetics MeSH
- Smoking adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasm Recurrence, Local MeSH
- Matrix Metalloproteinase 1 blood MeSH
- Matrix Metalloproteinase 2 blood MeSH
- Matrix Metalloproteinase 9 blood MeSH
- Biomarkers, Tumor blood MeSH
- Head and Neck Neoplasms blood MeSH
- Laryngeal Neoplasms blood MeSH
- Hypopharyngeal Neoplasms blood MeSH
- Oropharyngeal Neoplasms blood MeSH
- Pilot Projects MeSH
- Preoperative Period MeSH
- Prognosis MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Carcinoma, Squamous Cell blood MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cyclin-Dependent Kinase Inhibitor p16 MeSH
- Matrix Metalloproteinase 1 MeSH
- Matrix Metalloproteinase 2 MeSH
- Matrix Metalloproteinase 9 MeSH
- MMP1 protein, human MeSH Browser
- MMP2 protein, human MeSH Browser
- MMP9 protein, human MeSH Browser
- Biomarkers, Tumor MeSH
BACKGROUND: Head and neck squamous cell cancer (HNSCC) includes tumors of various anatomical sites sharing common etiological factors. Serum levels of MMP1, MMP2, and MMP9 were analyzed in patients with oropharyngeal, laryngeal, and hypopharyngeal carcinomas in an effort to elucidate the pathobiology and in order to find useful biomarkers of site-specific HNSCC. PATIENTS AND METHODS: The study group comprised of 46 patients with HNSCC (21 with oropharyngeal, 21 with laryngeal and 4 with hypopharyngeal cancer). Serum levels of MMP1, -2, and -9 were determined by the MAGPIX multiplex method. P16 protein was detected by immunohistochemistry. Serum levels of matrix metalloproteinases (MMPs) were correlated with clinicopathological features of carcinomas and were compared with respect to tumor site. RESULTS: Significant correlations were confirmed between p16 positivity and oropharyngeal cancer, MMP1 and p16 positivity, and recurrence and smoking. Statistically significant differences in serum levels of MMPs between cancer of different locations were not found. CONCLUSION: MMP1 expression is significantly affected by smoking habit and by p16 and might mediate etiopathogenetical process in cancerogenesis of HNSCC. Our pilot study did not establish any utility of MMP1, -2, or -9 in clinical practice as diagnostic/prognostic markers.
