The analysis of linear and monomethylalkanes in exhaled breath samples by GC×GC-FID and GC-MS/MS
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25531871
DOI
10.1016/j.jchromb.2014.11.026
PII: S1570-0232(14)00725-9
Knihovny.cz E-resources
- Keywords
- Exhaled breath, INCAT, Monomethylalkanes, Needle trap, n-Alkanes,
- MeSH
- Alkanes analysis chemistry MeSH
- Breath Tests methods MeSH
- Humans MeSH
- Limit of Detection MeSH
- Gas Chromatography-Mass Spectrometry methods MeSH
- Reproducibility of Results MeSH
- Tandem Mass Spectrometry methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Alkanes MeSH
A new arrangement of the INCAT (inside needle capillary adsorption trap) device with Carbopack X and Carboxen 1000 as sorbent materials was applied for sampling, preconcentration and injection of C6C19n-alkanes and their monomethyl analogs in exhaled breath samples. For the analysis both GC-MS/MS and GC×GC-FID techniques were used. Identification of the analytes was based on standards, measured retention indices and selective SRM transitions of the individual isomers. The GC-MS/MS detection limits were in the range from 2.1 pg for n-tetradecane to 86 pg for 5-methyloctadecane. The GC×GC-FID detection limits ranged from 19 pg for n-dodecane to 110 pg for 3-methyloctane.
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