The effect of ICD programming on inappropriate and appropriate ICD Therapies in ischemic and nonischemic cardiomyopathy: the MADIT-RIT trial
Language English Country United States Media print-electronic
Document type Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
25546486
DOI
10.1111/jce.12605
Knihovny.cz E-resources
- Keywords
- MADIT-RIT trial, appropriate ICD therapy, implantable cardioverter defibrillators, inappropriate ICD therapy, ischemic cardiomyopathy, nonischemic cardiomyopathy,
- MeSH
- Time Factors MeSH
- Defibrillators, Implantable * MeSH
- Equipment Design MeSH
- Electric Countershock adverse effects instrumentation mortality MeSH
- Electrophysiologic Techniques, Cardiac MeSH
- Myocardial Ischemia complications diagnosis mortality MeSH
- Kaplan-Meier Estimate MeSH
- Cardiomyopathies diagnosis etiology mortality physiopathology MeSH
- Tachycardia, Ventricular diagnosis etiology mortality physiopathology therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Multivariate Analysis MeSH
- Death, Sudden, Cardiac etiology prevention & control MeSH
- Signal Processing, Computer-Assisted MeSH
- Predictive Value of Tests MeSH
- Proportional Hazards Models MeSH
- Risk Factors MeSH
- Chi-Square Distribution MeSH
- Equipment Failure * MeSH
- Aged MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Geographicals
- Europe MeSH
- Israel MeSH
- United States MeSH
INTRODUCTION: The MADIT-RIT trial demonstrated reduction of inappropriate and appropriate ICD therapies and mortality by high-rate cut-off and 60-second-delayed VT therapy ICD programming in patients with a primary prophylactic ICD indication. The aim of this analysis was to study effects of MADIT-RIT ICD programming in patients with ischemic and nonischemic cardiomyopathy. METHODS AND RESULTS: First and total occurrences of both inappropriate and appropriate ICD therapies were analyzed by multivariate Cox models in 791 (53%) patients with ischemic and 707 (47%) patients with nonischemic cardiomyopathy. Patients with ischemic and nonischemic cardiomyopathy had similar incidence of first inappropriate (9% and 11%, P = 0.21) and first appropriate ICD therapy (11.6% and 14.1%, P = 0.15). Patients with ischemic cardiomyopathy had higher mortality rate (6.1% vs. 3.3%, P = 0.01). MADIT-RIT high-rate cut-off (arm B) and delayed VT therapy ICD programming (arm C) compared with conventional (arm A) ICD programming were associated with a significant risk reduction of first inappropriate and appropriate ICD therapy in patients with ischemic and nonischemic cardiomyopathy (HR range 0.11-0.34, P < 0.001 for all comparisons). Occurrence of total inappropriate and appropriate ICD therapies was significantly reduced by high-rate cut-off ICD programming and delayed VT therapy ICD programming in both ischemic and nonischemic cardiomyopathy patients. CONCLUSION: High-rate cut-off and delayed VT therapy ICD programming are associated with significant reduction in first and total inappropriate and appropriate ICD therapy in patients with ischemic and nonischemic cardiomyopathy.
Cardiology Department Institute for Clinical and Experimental Medicine Prague Czech Republic
Charite Universitätsmedizin Berlin Experimental and Clinical Research Centre Berlin Germany
Department of Cardiology Gentofte Hospital Hellerup Denmark
Faculty of Medicine University of Aalborg Aalborg Denmark
Heart Centre Semmelweis University Budapest Hungary
Hospital Infanta Christina Badajoz Spain
Kaplan Medical Centre Heart Institute Bitaniz Rehovot Israel
The Heart Research Follow up Program University of Rochester Medical Center Rochester New York USA
References provided by Crossref.org
ClinicalTrials.gov
NCT00947310
