Metal-based particles in human amniotic fluids of fetuses with normal karyotype and congenital malformation--a pilot study
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- amniocentéza MeSH
- difrakce rentgenového záření MeSH
- karyotyp MeSH
- kovy toxicita MeSH
- lidé MeSH
- mikroskopie elektronová rastrovací MeSH
- pilotní projekty MeSH
- plod * MeSH
- plodová voda chemie MeSH
- spektroskopie infračervená s Fourierovou transformací MeSH
- studie případů a kontrol MeSH
- těhotenství MeSH
- vrozené vady etiologie MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- kovy MeSH
This study explores the inorganic composition of amniotic fluid in healthy human fetuses and fetuses with congenital malformation with a special attention to presence of metal-based solid particles. Amniotic fluid originates from maternal blood and provides fetus mechanical protection and nutrients. In spite of this crucial role, the environmental impact on the composition of amniotic fluid remains poorly studied. The samples of human amniotic fluids were obtained by amniocentesis, including both healthy pregnancies and those with congenital malformations. The samples were analysed using several techniques, including Raman microspectroscopy, scanning electron microscopy with energy-dispersed spectrometry (SEM-EDS), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis. Several metal-based particles containing barium, titanium, iron, and other elements were detected by SEM-EDS and Raman microspectroscopy. XRD analysis detected only sodium chloride as the main component of all amniotic fluid samples. Infrared spectroscopy detected protein-like organic components. Majority of particles were in form of agglomerates up to tens of micrometres in size, consisting of mainly submicron particles. By statistical analysis (multiple correspondence analysis), it was observed that groups of healthy and diagnosed fetuses form two separate groups and therefore, qualitative differences in chemical composition may have distinct biological impact. Overall, our results suggest that metal-based nanosized pollutants penetrate into the amniotic fluid and may affect human fetuses.
Zobrazit více v PubMed
Epidemiology. 2004 Jan;15(1):36-45 PubMed
Environ Health Perspect. 2005 Jul;113(7):823-39 PubMed
Sci Total Environ. 2008 Aug 1;400(1-3):42-51 PubMed
J Chin Med Assoc. 2009 Jul;72(7):368-73 PubMed
Int J Mol Sci. 2013 Jul 31;14 (8):15910-30 PubMed
Int J Epidemiol. 1998 Apr;27(2):242-7 PubMed
Environ Health Perspect. 2005 Apr;113(4):375-82 PubMed
Eur J Epidemiol. 2005;20(2):183-99 PubMed
Arch Toxicol. 2010 Jun;84(6):447-60 PubMed
Exp Biol Med (Maywood). 2010 Sep;235(9):1025-33 PubMed
Lancet. 2002 Oct 19;360(9341):1233-42 PubMed
J Intern Med. 2007 May;261(5):412-7 PubMed
Pharmacol Res. 2010 Aug;62(2):126-43 PubMed
Curr Opin Microbiol. 2012 Feb;15(1):36-43 PubMed
Environ Health Perspect. 2011 May;119(5):598-606 PubMed
J Midwifery Womens Health. 2007 Sep-Oct;52(5):435-43 PubMed
Occup Environ Med. 2010 Apr;67(4):221-2 PubMed
Pharmacol Ther. 2008 Oct;120(1):35-42 PubMed
Birth Defects Res C Embryo Today. 2007 Sep;81(3):144-54 PubMed
Am Fam Physician. 2010 Jan 15;81(2):175-80 PubMed
Int Arch Occup Environ Health. 2001 Jan;74(1):1-8 PubMed
Environ Health Perspect. 2003 Feb;111(2):201-5 PubMed
Nat Rev Neurosci. 2008 Jul;9(7):519-31 PubMed
Environ Res. 2004 May;95(1):106-15 PubMed
Birth Defects Res A Clin Mol Teratol. 2003 Jul;67(7):529; author reply 530 PubMed
Pediatrics. 2004 Apr;113(4 Suppl):1037-43 PubMed
Anal Chim Acta. 2013 Feb 18;764:24-31 PubMed
Environ Health Perspect. 2002 Feb;110(2):197-204 PubMed
Front Biosci (Elite Ed). 2011 Jan 01;3:221-6 PubMed
Environ Int. 2011 Feb;37(2):498-516 PubMed
J Toxicol Environ Health B Crit Rev. 2008 May;11(5-6):373-517 PubMed
Int J Epidemiol. 2002 Apr;31(2):342-8 PubMed
