Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/pmid25630657
- Keywords
- cancer, fluorescent probes, methinium salt, mitochondrial localization, quinoxaline, tumor growth suppression,
- MeSH
- Quinoxalines chemistry therapeutic use MeSH
- Cyclization MeSH
- Hexamethonium chemistry therapeutic use MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Neoplasms drug therapy pathology MeSH
- Antineoplastic Agents chemistry therapeutic use MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Quinoxalines MeSH
- Hexamethonium MeSH
- Antineoplastic Agents MeSH
A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice.
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