Clinical Department of Nuclear Medicine Innsbruck Medical University Innsbruck Austria

Division of Molecular Biology Biocenter Innsbruck Medical University Innsbruck Austria

Institute of Molecular and Translational Medicine Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic

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Hayes GE, Denning DW (2013) Frequency, diagnosis and management of fungal respiratory infections. Curr Opin Pulm Med 19: 259–265. 10.1097/MCP.0b013e32835f1ad1 PubMed DOI

Pfaller MA, Diekema DJ (2010) Epidemiology of invasive mycoses in North America. Crit Rev Microbiol 36: 1–53. 10.3109/10408410903241444 PubMed DOI

Steinbach WJ (2013) Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosis. PLoS Pathog 9: e1003642 10.1371/journal.ppat.1003642 PubMed DOI PMC

Maertens JA, Nucci M, Donnelly JP (2012) The role of antifungal treatment in hematology. Haematologica 97: 325–327. 10.3324/haematol.2012.061952 PubMed DOI PMC

Lin M, Shon IH, Lin P (2010) Positron emission tomography: current status and future challenges. Intern Med J 40: 19–29. 10.1111/j.1445-5994.2009.02072.x PubMed DOI

Haubner R (2010) PET radiopharmaceuticals in radiation treatment planning—synthesis and biological characteristics. Radiother Oncol 96: 280–287. 10.1016/j.radonc.2010.07.022 PubMed DOI

Wadsak W, Mitterhauser M (2010) Basics and principles of radiopharmaceuticals for PET/CT. Eur J Radiol 73: 461–469. 10.1016/j.ejrad.2009.12.022 PubMed DOI

Signore A, Glaudemans AW (2011) The molecular imaging approach to image infections and inflammation by nuclear medicine techniques. Ann Nucl Med 25: 681–700. 10.1007/s12149-011-0521-z PubMed DOI

Lupetti A, de Boer MG, Erba P, Campa M, Nibbering PH (2011) Radiotracers for fungal infection imaging. Med Mycol 49 Suppl 1: S62–69. 10.3109/13693786.2010.508188 PubMed DOI

Kwon-Chung KJ, Sugui JA (2013) Aspergillus fumigatus--what makes the species a ubiquitous human fungal pathogen? PLoS Pathog 9: e1003743 10.1371/journal.ppat.1003743 PubMed DOI PMC

Wang Y, Chen L, Liu X, Cheng D, Liu G, et al. (2013) Detection of Aspergillus fumigatus pulmonary fungal infections in mice with (99m)Tc-labeled MORF oligomers targeting ribosomal RNA. Nucl Med Biol 40: 89–96. 10.1016/j.nucmedbio.2012.10.001 PubMed DOI PMC

Yang Z, Kontoyiannis DP, Wen X, Xiong C, Zhang R, et al. (2009) Gamma scintigraphy imaging of murine invasive pulmonary aspergillosis with a (111)In-labeled cyclic peptide. Nucl Med Biol 36: 259–266. 10.1016/j.nucmedbio.2008.12.004 PubMed DOI

Thornton CR (2014) Breaking the mould—novel diagnostic and therapeutic strategies for invasive pulmonary aspergillosis in the immune deficient patient. Expert Rev Clin Immunol 10: 771–780. 10.1586/1744666X.2014.904747 PubMed DOI

Cassat JE, Skaar EP (2013) Iron in infection and immunity. Cell Host Microbe 13: 509–519. 10.1016/j.chom.2013.04.010 PubMed DOI PMC

Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, et al. (2004) Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med 200: 1213–1219. 10.1084/jem.20041242 PubMed DOI PMC

McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, et al. (2008) Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog 4: e1000154 10.1371/journal.ppat.1000154 PubMed DOI PMC

Schrettl M, Kim HS, Eisendle M, Kragl C, Nierman WC, et al. (2008) SreA-mediated iron regulation in Aspergillus fumigatus . Mol Microbiol 70: 27–43. 10.1111/j.1365-2958.2008.06376.x PubMed DOI PMC

Hider RC, Kong X (2010) Chemistry and biology of siderophores. Nat Prod Rep 27: 637–657. 10.1039/b906679a PubMed DOI

Hissen AH, Moore MM (2005) Site-specific rate constants for iron acquisition from transferrin by the Aspergillus fumigatus siderophores N′,N′′,N′′′-triacetylfusarinine C and ferricrocin. J Biol Inorg Chem 10: 211–220. 10.1007/s00775-005-0630-z PubMed DOI

Haas H (2012) Iron—A Key Nexus in the Virulence of Aspergillus fumigatus . Front Microbiol 3: 28 10.3389/fmicb.2012.00028 PubMed DOI PMC

Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, et al. (2007) Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection. PLoS Pathog 3: e128 10.1371/journal.ppat.0030128 PubMed DOI PMC

Yasmin S, Alcazar-Fuoli L, Grundlinger M, Puempel T, Cairns T, et al. (2012) Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus . Proc Natl Acad Sci U S A 109: E497–504. 10.1073/pnas.1106399108 PubMed DOI PMC

Haas H, Eisendle M, Turgeon BG (2008) Siderophores in fungal physiology and virulence. Annu Rev Phytopathol 46: 149–187. 10.1146/annurev.phyto.45.062806.094338 PubMed DOI

Raymond-Bouchard I, Carroll CS, Nesbitt JR, Henry KA, Pinto LJ, et al. (2012) Structural requirements for the activity of the MirB ferrisiderophore transporter of Aspergillus fumigatus . Eukaryot Cell 11: 1333–1344. 10.1128/EC.00159-12 PubMed DOI PMC

Haas H, Schoeser M, Lesuisse E, Ernst JF, Parson W, et al. (2003) Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C. Biochem J 371: 505–513. 10.1042/BJ20021685 PubMed DOI PMC

Kragl C, Schrettl M, Abt B, Sarg B, Lindner HH, et al. (2007) EstB-mediated hydrolysis of the siderophore triacetylfusarinine C optimizes iron uptake of Aspergillus fumigatus . Eukaryot Cell 6: 1278–1285. 10.1128/EC.00066-07 PubMed DOI PMC

Grundlinger M, Gsaller F, Schrettl M, Lindner H, Haas H (2013) Aspergillus fumigatus SidJ mediates intracellular siderophore hydrolysis. Appl Environ Microbiol 79: 7534–7536. 10.1128/AEM.01285-13 PubMed DOI PMC

Gsaller F, Eisendle M, Lechner BE, Schrettl M, Lindner H, et al. (2012) The interplay between vacuolar and siderophore-mediated iron storage in Aspergillus fumigatus . Metallomics 4: 1262–1270. 10.1039/c2mt20179h PubMed DOI

Philpott CC (2006) Iron uptake in fungi: a system for every source. Biochim Biophys Acta 1763: 636–645. 10.1016/j.bbamcr.2006.05.008 PubMed DOI

Petrik M, Haas H, Schrettl M, Helbok A, Blatzer M, et al. (2012) In vitro and in vivo evaluation of selected 68Ga-siderophores for infection imaging. Nucl Med Biol 39: 361–369. 10.1016/j.nucmedbio.2011.09.012 PubMed DOI PMC

Llinas M, Klein MP, Neilands JB (1970) Solution conformation of ferrichrome, a microbial iron transport cyclohexapeptide, as deduced by high resolution proton magnetic resonance. J Mol Biol 52: 399–414. 10.1016/0022-2836(70)90409-2 PubMed DOI

Emery T, Hoffer PB (1980) Siderophore-mediated mechanism of gallium uptake demonstrated in the microorganism Ustilago sphaerogena. J Nucl Med 21: 935–939. PubMed

Velikyan I (2013) Prospective of (6)(8)Ga-radiopharmaceutical development. Theranostics 4: 47–80. 10.7150/thno.7447 PubMed DOI PMC

Petrik M, Haas H, Dobrozemsky G, Lass-Florl C, Helbok A, et al. (2010) 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med 51: 639–645. 10.2967/jnumed.109.072462 PubMed DOI PMC

Barona-Gomez F, Wong U, Giannakopulos AE, Derrick PJ, Challis GL (2004) Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145. J Am Chem Soc 126: 16282–16283. 10.1021/ja045774k PubMed DOI

Petrik M, Franssen GM, Haas H, Laverman P, Hortnagl C, et al. (2012) Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging. Eur J Nucl Med Mol Imaging 39: 1175–1183. 10.1007/s00259-012-2110-3 PubMed DOI PMC

Sia AK, Allred BE, Raymond KN (2013) Siderocalins: Siderophore binding proteins evolved for primary pathogen host defense. Curr Opin Chem Biol 17: 150–157. 10.1016/j.cbpa.2012.11.014 PubMed DOI PMC

Petrik M, Haas H, Laverman P, Schrettl M, Franssen GM, et al. (2014) 68Ga-triacetylfusarinine C and 68Ga-ferrioxamine E for Aspergillus infection imaging: uptake specificity in various microorganisms. Mol Imaging Biol 16: 102–108. 10.1007/s11307-013-0654-7 PubMed DOI PMC

Siderophore-Based Molecular Imaging of Fungal and Bacterial Infections-Current Status and Future Perspectives

Imaging of Pseudomonas aeruginosa infection with Ga-68 labelled pyoverdine for positron emission tomography

Early and Non-invasive Diagnosis of Aspergillosis Revealed by Infection Kinetics Monitored in a Rat Model

Siderophores for molecular imaging applications