Tetraloop-like geometries could form the basis of the catalytic activity of the most ancient ribooligonucleotides
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25640446
DOI
10.1002/chem.201406140
Knihovny.cz E-zdroje
- Klíčová slova
- RNA, catalysis, molecular dynamics, oligonucleotides, ribozymes,
- MeSH
- katalýza MeSH
- kinetika MeSH
- oligonukleotidy chemická syntéza chemie MeSH
- RNA katalytická chemie MeSH
- sekvence nukleotidů MeSH
- simulace molekulární dynamiky MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- oligonukleotidy MeSH
- RNA katalytická MeSH
The origin of the catalytic activity of ancient oligonucleotides is a largely unexplored field of contemporary science. In the current work we use molecular dynamics simulations to investigate the plausibility of tetraloop-like overhang geometries to initiate transphosphorylation reactions that lead to ligation and terminal cleavage in simple, Watson-Crick (WC) complementary oligoC/oligoG sequences observed experimentally. We show a series of examples of known tetraloop architectures, which can be adopted by the unpaired overhangs of short oligonucleotide sequences for a sufficiently long time to enable chemical reactions that lead to simple ribozyme-like catalytic activity. Thus, our computations demonstrate that the role of non-WC interactions at the emergence of the most ancient catalytic oligonucleotides could be more significant than ever believed.
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