Polymer brushes interfacing blood as a route toward high performance blood contacting devices
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- blood compatibility, blood plasma, non-fouling, proteins, surfaces,
- MeSH
- Coated Materials, Biocompatible chemistry MeSH
- Biofouling MeSH
- Cell Adhesion MeSH
- Photoelectron Spectroscopy MeSH
- Blood metabolism MeSH
- Humans MeSH
- Microscopy, Atomic Force MeSH
- Platelet-Rich Plasma MeSH
- Polymerization MeSH
- Polymers chemical synthesis chemistry MeSH
- Surface Properties MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Materials Testing instrumentation MeSH
- Water MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Coated Materials, Biocompatible MeSH
- Polymers MeSH
- Water MeSH
In the current study, well-defined polymer brushes are shown as an effective surface modification to resist the adhesion of whole blood and its components. Poly[oligo(ethylene glycol)methylether methacrylate] (poly(MeOEGMA)), poly(hydroxyethyl methacrylate) (poly(HEMA)), poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)), and poly(carboxybetaine acrylamide) (poly(CBAA)) brushes were grown by surface initiated atom transfer radical polymerization (SI-ATRP) and subsequently characterized by Fourier-transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), dynamic contact angle measurements, atomic force microscopy (AFM), and surface plasmon resonance (SPR) spectroscopy. All brushes decreased the fouling from blood plasma over 95% and prevented the adhesion of platelets, erythrocytes, and leukocytes as evidenced by SPR and SEM measurements.
Institute for Applied Materials Hermann von Helmholtz Platz 1 76344 Eggenstein Leopoldshafen Germany
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