An effective strategy of magnetic stem cell delivery for spinal cord injury therapy
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25652717
DOI
10.1039/c4nr05791k
Knihovny.cz E-resources
- MeSH
- Microscopy, Fluorescence MeSH
- Stem Cells chemistry cytology metabolism MeSH
- Magnetite Nanoparticles chemistry MeSH
- Magnetic Fields MeSH
- Mice MeSH
- Ferrosoferric Oxide chemistry MeSH
- Spinal Cord Injuries therapy MeSH
- Stem Cell Transplantation * MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Magnetite Nanoparticles MeSH
- Ferrosoferric Oxide MeSH
Spinal cord injury (SCI) is a condition that results in significant mortality and morbidity. Treatment of SCI utilizing stem cell transplantation represents a promising therapy. However, current conventional treatments are limited by inefficient delivery strategies of cells into the injured tissue. In this study, we designed a magnetic system and used it to accumulate stem cells labelled with superparamagnetic iron oxide nanoparticles (SPION) at a specific site of a SCI lesion. The loading of stem cells with engineered SPIONs that guarantees sufficient attractive magnetic forces was achieved. Further, the magnetic system allowed rapid guidance of the SPION-labelled cells precisely to the lesion location. Histological analysis of cell distribution throughout the cerebrospinal channel showed a good correlation with the calculated distribution of magnetic forces exerted onto the transplanted cells. The results suggest that focused targeting and fast delivery of stem cells can be achieved using the proposed non-invasive magnetic system. With future implementation the proposed targeting and delivery strategy bears advantages for the treatment of disease requiring fast stem cell transplantation.
References provided by Crossref.org
Biomaterials and Magnetic Stem Cell Delivery in the Treatment of Spinal Cord Injury
Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview
