An effective strategy of magnetic stem cell delivery for spinal cord injury therapy

. 2015 Mar 07 ; 7 (9) : 3954-8.

Jazyk angličtina Země Anglie, Velká Británie Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid25652717

Spinal cord injury (SCI) is a condition that results in significant mortality and morbidity. Treatment of SCI utilizing stem cell transplantation represents a promising therapy. However, current conventional treatments are limited by inefficient delivery strategies of cells into the injured tissue. In this study, we designed a magnetic system and used it to accumulate stem cells labelled with superparamagnetic iron oxide nanoparticles (SPION) at a specific site of a SCI lesion. The loading of stem cells with engineered SPIONs that guarantees sufficient attractive magnetic forces was achieved. Further, the magnetic system allowed rapid guidance of the SPION-labelled cells precisely to the lesion location. Histological analysis of cell distribution throughout the cerebrospinal channel showed a good correlation with the calculated distribution of magnetic forces exerted onto the transplanted cells. The results suggest that focused targeting and fast delivery of stem cells can be achieved using the proposed non-invasive magnetic system. With future implementation the proposed targeting and delivery strategy bears advantages for the treatment of disease requiring fast stem cell transplantation.

Citace poskytuje Crossref.org

Nejnovějších 20 citací...

Zobrazit více v
Medvik | PubMed

Combined Therapy Using Mesenchymal Stem Cells and Metal Nanoparticles: Perspectives for Ocular Injuries and Diseases

. 2025 ; 20 () : 7403-7414. [epub] 20250612

Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis

. 2020 May 19 ; 7 (1) : 17. [epub] 20200519

Biomaterials and Magnetic Stem Cell Delivery in the Treatment of Spinal Cord Injury

. 2020 Jan ; 45 (1) : 171-179. [epub] 20190426

Remote Actuation of Apoptosis in Liver Cancer Cells via Magneto-Mechanical Modulation of Iron Oxide Nanoparticles

. 2019 Nov 26 ; 11 (12) : . [epub] 20191126

Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview

. 2019 Jan 11 ; 11 (1) : . [epub] 20190111

A Critical Review on Selected External Physical Cues and Modulation of Cell Behavior: Magnetic Nanoparticles, Non-thermal Plasma and Lasers

. 2018 Dec 24 ; 10 (1) : . [epub] 20181224

Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines

. 2017 Nov 22 ; 7 (1) : 16049. [epub] 20171122

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...