Prenatal methamphetamine exposure induces long-lasting alterations in memory and development of NMDA receptors in the hippocampus
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25669686
DOI
10.33549/physiolres.932926
PII: 932926
Knihovny.cz E-resources
- MeSH
- Maze Learning drug effects MeSH
- Hippocampus drug effects metabolism MeSH
- Methamphetamine administration & dosage toxicity MeSH
- Random Allocation MeSH
- Rats, Wistar MeSH
- Spatial Memory drug effects MeSH
- Receptors, N-Methyl-D-Aspartate metabolism MeSH
- Central Nervous System Stimulants administration & dosage toxicity MeSH
- Pregnancy MeSH
- Blotting, Western MeSH
- Prenatal Exposure Delayed Effects * MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Methamphetamine MeSH
- Receptors, N-Methyl-D-Aspartate MeSH
- Central Nervous System Stimulants MeSH
Since close relationship was shown between drug addiction and memory formation, the aim of the present study was to investigate the effects of interaction between prenatal methamphetamine (MA) exposure and MA treatment in adulthood on spatial and non-spatial memory and on the structure of the N-methyl-D-aspartate (NMDA) receptors in the hippocampus. Adult male rats prenatally exposed to MA (5 mg/kg) or saline were tested in adulthood. Non-spatial memory was examined in the Object Recognition Test (ORT) and spatial memory in the Object Location Test (OLT) and in the Memory Retention Test (MRT) conducted in the Morris Water Maze (MWM), respectively. Based on the type of the memory test animals were injected either acutely (ORT, OLT) or long-term (MWM) with MA (1 mg/kg). After each testing, animals were sacrificed and brains were removed. The hippocampus was then examined in Western Blot analysis for occurrence of different NMDA receptors' subtypes. Our results demonstrated that prenatal MA exposure affects the development of the NMDA receptors in the hippocampus that might correspond with improvement of spatial memory tested in adulthood in the MWM. On the other hand, the effect of prenatal MA exposure on non-spatial memory examined in the ORT was the opposite. In addition, we showed that the effect of MA administration in adulthood on NMDA receptors is influenced by prenatal MA exposure, which seems to correlate with the spatial memory examined in the OLT.
References provided by Crossref.org
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