Stimulatory effect of sesamin on hepatic cytochrome P450 activities in Atlantic salmon (Salmo salar L.) is not directly associated with expression of genes related to xenobiotic metabolism
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Fish, induction, xenobiotic metabolizing enzymes,
- MeSH
- Dioxoles pharmacology MeSH
- Liver drug effects enzymology MeSH
- Lignans pharmacology MeSH
- Plant Oils pharmacology MeSH
- Gene Expression Regulation drug effects MeSH
- Fish Oils pharmacology MeSH
- Salmo salar metabolism MeSH
- Cytochrome P-450 Enzyme System metabolism MeSH
- Xenobiotics metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dioxoles MeSH
- Lignans MeSH
- Plant Oils MeSH
- Fish Oils MeSH
- sesamin MeSH Browser
- Cytochrome P-450 Enzyme System MeSH
- Xenobiotics MeSH
1. This study examined hepatic cytochrome P450 (CYP450) response to dietary sesamin in combination with different n-6/n-3 fatty acid ratios in fish diet. Over a period of 4 months, fish were fed seven different experimental diets an n-6/n-3 FA ratio of either 0.5 or 1.0 in combination with two sesamin levels: low sesamin = 1.16 g/kg feed and high sesamin = 5.8 g/kg feed. Control diets did not contain sesamin. 2. The CYP450-associated activities of ethoxyresorufin O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylation (BFCOD), pentoxyresorufin O-depentylase (PROD), coumarin hydroxylase (COH), methoxyresorufin O-deethylase (MROD) and p-nitrophenol hydroxylase (PNPH) were significantly induced by dietary sesamin in a dose-related manner. 3. Expressions of the genes CYP1A1, CYP1A3, CYP3A, AhR1α, AhR2β, AhR2δ and PXR involved in the regulation of CYP450 activities, was not the primary source of this induction.
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