Analysis of serum levels of cytokines, chemokines, growth factors, and monoamine neurotransmitters in patients with tick-borne encephalitis: identification of novel inflammatory markers with implications for pathogenesis
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25675945
DOI
10.1002/jmv.24140
Knihovny.cz E-resources
- Keywords
- luminex, neuroinfection, neuroinflammation, tick-borne encephalitis virus,
- MeSH
- Biogenic Monoamines blood MeSH
- Cytokines blood MeSH
- Child MeSH
- Adult MeSH
- Immunoassay MeSH
- Encephalitis, Tick-Borne pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Intercellular Signaling Peptides and Proteins blood MeSH
- Adolescent MeSH
- Young Adult MeSH
- Neurotransmitter Agents blood MeSH
- Child, Preschool MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Serum chemistry MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biogenic Monoamines MeSH
- Cytokines MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- Neurotransmitter Agents MeSH
Tick-borne encephalitis (TBE) is a leading human neuroinfection in Europe and northeastern Asia. However, the pathophysiology of TBE is not understood completely. This study sought to determine the specific serum mediators that are associated with acute TBE. The levels of 30 cytokines, chemokines, and growth factors were measured in serum samples from 87 patients with clinically and serologically confirmed acute TBE and from 32 control subjects using the Cytokine Human Magnetic 30-Plex Panel for the Luminex platform. Serum levels of the monoamine neurotransmitters serotonin, dopamine, and noradrenaline were measured via enzyme-linked immunosorbent assay. TBE virus infection elicited increased levels of the pro-inflammatory cytokines interleukin (IL)-6, IL-8, and IL-12. TBE patients had higher IL-12:IL-4 and IL-12:IL-10 ratios than control patients, reflecting the global pro-inflammatory cytokine balance. Serum levels of the monoamine neurotransmitters serotonin, dopamine, and noradrenaline were significantly lower in TBE patients than in the control group. Most interestingly, increased levels of hepatocyte growth factor and vascular endothelial growth factor were observed in TBE patients; these proteins may be novel and mechanistically important inflammatory biomarkers of TBE.
References provided by Crossref.org
History of Arbovirus Research in the Czech Republic
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