Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
PubMed
25779579
PubMed Central
PMC4432209
DOI
10.1128/aac.05016-14
PII: AAC.05016-14
Knihovny.cz E-zdroje
- MeSH
- antivirové látky terapeutické užití MeSH
- dospělí MeSH
- herpetická encefalitida diagnóza farmakoterapie MeSH
- interval spolehlivosti MeSH
- lidé středního věku MeSH
- lidé MeSH
- retrospektivní studie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Názvy látek
- antivirové látky MeSH
Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
Aalborg University Hospital Department of Infectious Diseases Aalborg Denmark
Aarhus University Hospital Department of Infectious Diseases Aarhus Denmark
American University of Beirut Medical Center Beirut Lebanon
Assiut University Hospital Department of Neurology and Psychiatry Assiut Egypt
Bezmi Alem Vakif University School of Medicine Department of Neurology Istanbul Turkey
Department of Neurology Baghdad Teaching Hospital Baghdad Iraq
Haydarpaşa Numune Training and Research Hospital Department of Neurology Istanbul Turkey
Haydarpaşa Numune Training and Research Hospital Department of Radiology Istanbul Turkey
Hvidovre Hospital Department of Infectious Diseases Copenhagen Denmark
Infectious Diseases and Intensive Care Unit Pontchaillou University Hospital Rennes France
Nouvel Hôpital Civil Department of Infectious Diseases Strasbourg France
Odense University Hospital Department of Infectious Diseases Q Odense Denmark
Poitiers University Hospital Department of Infectious Diseases Poitiers France
Private Umit Hospital Department of Infectious Diseases and Clinical Microbiology Eskisehir Turkey
University Medical Centre Department of Infectious Diseases Ljubljana Slovenia
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