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PubMed

Záznam pochází z PubMed

The burden and epidemiology of community-acquired central nervous system infections: a multinational study

European journal of clinical microbiology & infectious diseases. 2017 Sep ; 36 (9) : 1595-1611. [epub] 20170410

Eur J Clin Microbiol Infect Dis
ISSN 1435-4373 | 0934-9723
Zdroj

Jazyk angličtina Země Německo Médium print-electronic

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz https://www.medvik.cz/link/pmid28397100

PubMed 28397100
DOI 10.1007/s10096-017-2973-0
PII: 10.1007/s10096-017-2973-0
Knihovny.cz E-zdroje

Klíčová slova
Adverse Clinical Outcome, Brain Abscess, Central Nervous System Disease, Central Nervous System Infection, Human Immunodeficiency Virus,
MeSH
dospělí MeSH
hodnocení výsledků zdravotní péče MeSH
infekce centrálního nervového systému epidemiologie etiologie mortalita MeSH
infekce získané v komunitě epidemiologie etiologie mortalita MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
průřezové studie MeSH
retrospektivní studie MeSH
senioři nad 80 let MeSH
senioři MeSH
surveillance populace * MeSH
věkové faktory MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH

Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.

The burden and epidemiology of community-acquired central nervous system infections: a multinational study

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