Recent-onset dilated cardiomyopathy associated with Borrelia burgdorferi infection
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu klinické zkoušky kontrolované, časopisecké články, práce podpořená grantem
PubMed
25939436
DOI
10.1007/s00059-015-4308-1
PII: 10.1007/s00059-015-4308-1
Knihovny.cz E-zdroje
- Klíčová slova
- Antibiotics, Borrelia burgdorferi, Dilated cardiomyopathy, Endomyocardial biopsy, Lyme disease,
- MeSH
- antibakteriální látky aplikace a dávkování MeSH
- bakteriální endokarditida diagnóza farmakoterapie mikrobiologie MeSH
- Borrelia burgdorferi izolace a purifikace MeSH
- ceftriaxon aplikace a dávkování MeSH
- dilatační kardiomyopatie diagnóza farmakoterapie mikrobiologie MeSH
- injekce intravenózní MeSH
- kardiotonika aplikace a dávkování MeSH
- kombinovaná farmakoterapie metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymeská nemoc diagnóza farmakoterapie mikrobiologie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky kontrolované MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- ceftriaxon MeSH
- kardiotonika MeSH
BACKGROUND: Several recent small studies have suggested a causal link between Lyme disease and dilated cardiomyopathy (DCM) by demonstrating the presence of the Borrelia burgdorferi (Bb) genome in the myocardium of patients with recent-onset DCM. The aim of this study was to further investigate the effect of targeted antibiotic treatment of Bb-related recent-onset DCM in a larger cohort of patients. PATIENTS AND METHODS: We performed endomyocardial biopsy (EMB) in 110 individuals (53 ± 11 years, 34 women) with recent-onset unexplained DCM, and detected the Bb genome in 22 (20 %) subjects. Bb-positive patients were subsequently treated with intravenous ceftriaxone for 21 days in addition to conventional heart failure medication. RESULTS: At the 1-year follow-up, a significant improvement in left ventricular (LV) ejection fraction (26 ± 6 vs. 44 ± 12 %; p < 0.01) and a decrease in LV end-diastolic (69 ± 7 vs. 63 ± 11 mm; p < 0.01) and end-systolic (61 ± 9 vs. 52 ± 4 mm; p < 0.01) diameters were documented. Moreover, a significant improvement in heart failure symptoms (NYHA class 3.4 ± 0.6 vs. 1.5 ± 0.7; p < 0.01) was also observed. CONCLUSION: Targeted antibiotic treatment of Bb-related recent-onset DCM in addition to conventional heart failure therapy is associated with favorable cardiac remodeling and improvement of heart failure symptoms.
International Clinical Research Center St Anne's University Hospital in Brno Brno Czech Republic
The National Institute of Public Health Prague Czech Republic
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