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Assessment of silver nanoparticle toxicity for common carp (Cyprinus carpio) fish embryos using a novel method controlling the agglomeration in the aquatic media

Oprsal, Jakub
Author Oprsal, Jakub Faculty of Chemical Technology, Institute of Environmental and Chemical Engineering, University of Pardubice, Studentská 537, CZ-53210, Pardubice, Czech Republic. jakub.oprsal@upce.cz
Blaha, Ludek
Author Blaha, Ludek Faculty of Science, Masaryk University, RECETOX, Kamenice 5, 62500, Brno, Czech Republic
Pouzar, Miloslav
Author Pouzar, Miloslav Faculty of Chemical Technology, Institute of Environmental and Chemical Engineering, University of Pardubice, Studentská 537, CZ-53210, Pardubice, Czech Republic
Knotek, Petr
Author Knotek, Petr Faculty of Chemical Technology, Department of General and Inorganic Chemistry, University of Pardubice, CZ-53210, Pardubice, Czech Republic
Vlcek, Milan
Author Vlcek, Milan Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 120 06, Prague, Czech Republic
Hrda, Katerina
Author Hrda, Katerina Faculty of Chemical Technology, Institute of Environmental and Chemical Engineering, University of Pardubice, Studentská 537, CZ-53210, Pardubice, Czech Republic

Environmental science and pollution research international. 2015 Dec ; 22 (23) : 19124-32. [epub] 20150802

Environ Sci Pollut Res Int
ISSN 1614-7499 | 0944-1344
Source

Language English Country Germany Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid26233755

PubMed 26233755
DOI 10.1007/s11356-015-5120-4
PII: 10.1007/s11356-015-5120-4
Knihovny.cz E-resources

Keywords
Agglomeration, Cyprinus carpio, Fish embryo, Nanosilver, Particle size distribution,
MeSH
Water Pollutants, Chemical toxicity MeSH
Embryo, Nonmammalian drug effects metabolism MeSH
Carps MeSH
Kinetics MeSH
Colloids MeSH
Metal Nanoparticles toxicity MeSH
Silver toxicity MeSH
Particle Size MeSH
Animals MeSH
Check Tag
Animals MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
Water Pollutants, Chemical MeSH
Colloids MeSH
Silver MeSH

Formation of agglomerates and their rapid sedimentation during aquatic ecotoxicity testing of nanoparticles is a major issue with a crucial influence on the risk assessment of nanomaterials. The present work is aimed at developing and testing a new approach based on the periodic replacement of liquid media during an ecotoxicological experiment which enabled the efficient monitoring of exposure conditions. A verified mathematical model predicted the frequencies of media exchanges which checked for formation of agglomerates from silver nanoparticles AgNP with 50 nm average size of the original colloid. In the model experiments, embryos of common carp Cyprinus carpio were exposed repeatedly for 6 h to AgNPs (5-50 μm Ag L(-1)) either under semistatic conditions (exchange of media after 6 h) or in variants with frequent media exchanges (varying from 20 to 300 min depending on the AgNP colloid concentration and the desired maximum agglomerate size of 200 or 400 nm). In contrast to other studies, where dissolved free metals are usually responsible for toxic effects, our 144-h experiments demonstrated the importance of AgNP agglomerates in the adverse effects of nanosilver. Direct adsorption of agglomerates on fish embryos locally increased Ag concentrations which resulted in pronounced toxicity particularly in variants with larger 400 nm agglomerates. The present study demonstrates the suitability of the novel methodology in controlling the conditions during aquatic nanomaterial toxicity testing. It further provided insights into the mechanisms underlying the effects of AgNP, which rank on a global scale among the most widely used nanomaterials.

Faculty of Chemical Technology Department of General and Inorganic Chemistry University of Pardubice CZ 53210 Pardubice Czech Republic

Faculty of Chemical Technology Institute of Environmental and Chemical Engineering University of Pardubice Studentská 537 CZ 53210 Pardubice Czech Republic

Faculty of Science Masaryk University RECETOX Kamenice 5 62500 Brno Czech Republic

Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic Heyrovsky sq 2 120 06 Prague Czech Republic

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