Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia
Language English Country United States Media print-electronic
Document type Journal Article, Review
PubMed
26254105
DOI
10.1016/j.vph.2015.08.005
PII: S1537-1891(15)00181-0
Knihovny.cz E-resources
- Keywords
- Angiogenesis, Apelin, Apelin-12 (PubChem CID: 479167), Apelin-13 (PubChem CID: 71433878), Apelin-36 (PubChem CID: 16130451), Endothelial cells, Myocardial infarction, Signalling pathways, [Pyr1]-apelin-13 (PubChem CID: 25078060),
- MeSH
- Endothelial Cells metabolism MeSH
- Neovascularization, Physiologic physiology MeSH
- Myocardial Infarction metabolism MeSH
- Intracellular Signaling Peptides and Proteins metabolism MeSH
- Myocardial Ischemia metabolism MeSH
- Humans MeSH
- Neovascularization, Pathologic metabolism MeSH
- Signal Transduction physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Intracellular Signaling Peptides and Proteins MeSH
Apelin is a peptide known to have a vital role in cardiovascular diseases. It has been proven to induce proliferation and tube formation in endothelial cells, stabilise contacts between endothelial cells, and mediate pericyte recruitment. Since apelin level is reduced early after myocardial infarction, a supportive therapy with apelin is being investigated for its beneficial effect on blood vessel formation. It is becoming apparent, however, that the final effect of apelin often depends on stimuli the cell receives and the cross-talk with other molecules inside the cell. Hence, understanding the apelin pathway potentially can help us to improve angiogenic therapy. This review summarises recent knowledge regarding molecules involved in apelin signalling while focusing on their roles in angiogenesis within the ischemic environment after myocardial infarction.
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