Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
26254105
DOI
10.1016/j.vph.2015.08.005
PII: S1537-1891(15)00181-0
Knihovny.cz E-zdroje
- Klíčová slova
- Angiogenesis, Apelin, Apelin-12 (PubChem CID: 479167), Apelin-13 (PubChem CID: 71433878), Apelin-36 (PubChem CID: 16130451), Endothelial cells, Myocardial infarction, Signalling pathways, [Pyr1]-apelin-13 (PubChem CID: 25078060),
- MeSH
- endoteliální buňky metabolismus MeSH
- fyziologická neovaskularizace fyziologie MeSH
- infarkt myokardu metabolismus MeSH
- intracelulární signální peptidy a proteiny metabolismus MeSH
- ischemická choroba srdeční metabolismus MeSH
- lidé MeSH
- patologická angiogeneze metabolismus MeSH
- signální transdukce fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- intracelulární signální peptidy a proteiny MeSH
Apelin is a peptide known to have a vital role in cardiovascular diseases. It has been proven to induce proliferation and tube formation in endothelial cells, stabilise contacts between endothelial cells, and mediate pericyte recruitment. Since apelin level is reduced early after myocardial infarction, a supportive therapy with apelin is being investigated for its beneficial effect on blood vessel formation. It is becoming apparent, however, that the final effect of apelin often depends on stimuli the cell receives and the cross-talk with other molecules inside the cell. Hence, understanding the apelin pathway potentially can help us to improve angiogenic therapy. This review summarises recent knowledge regarding molecules involved in apelin signalling while focusing on their roles in angiogenesis within the ischemic environment after myocardial infarction.
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