Hyperfractionated stereotactic reirradiation for recurrent head and neck cancer
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
26314584
DOI
10.1007/s00066-015-0886-3
PII: 10.1007/s00066-015-0886-3
Knihovny.cz E-zdroje
- Klíčová slova
- Overall survival, Reirradiation, Squamous cell carcinoma of the head and neck, Stereotactic radiotherapy, Toxicity,
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru patologie chirurgie MeSH
- míra přežití MeSH
- opakovaná terapie MeSH
- otorinolaryngologické nádory patologie chirurgie MeSH
- pooperační komplikace etiologie MeSH
- progrese nemoci MeSH
- radiochirurgie metody MeSH
- sekundární malignity patologie chirurgie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- spinocelulární karcinom patologie chirurgie MeSH
- staging nádorů MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
PURPOSE: The goal of this work was to evaluate the efficacy and toxicity of hyperfractionated stereotactic reirradiation (re-RT) as a treatment for inoperable, recurrent, or second primary head and neck squamous cell cancer (HNSCC) that is not suitable for systemic treatment. PATIENTS AND MATERIALS: Forty patients with recurrent or second primary HNSCC were included in this study. The patients had a median gross tumor volume of 76 ml (range 14-193 ml) and a previous radiotherapy dose greater than 60 Gy. Treatment was designed to cover 95 % of the planning target volume (PTV, defined as gross tumor volume [GTV] + 3 mm to account for microscopic spreading, with no additional set-up margin) with the prescribed dose (48 Gy in 16 fractions b.i.d.). Treatment was administered twice daily with a minimum 6 h gap. Uninvolved lymph nodes were not irradiated. RESULTS: Treatment was completed as planned for all patients (with median duration of 11 days, range 9-14 days). Acute toxicity was evaluated using the RTOG/EORTC scale. A 37 % incidence of grade 3 mucositis was observed, with recovery time of ≤ 4 weeks for all of these patients. Acute skin toxicity was never observed to be higher than grade 2. Late toxicity was also evaluated according to the RTOG/EORTC scale. Mandible radionecrosis was seen in 4 cases (10 %); however, neither carotid blowout syndrome nor other grade 4 late toxicity occurred. One-year overall survival (OS) and local progression-free survival (L-PFS) were found to be 33 and 44 %, respectively. Performance status and GTV proved to be significant prognostic factors regarding local control and survival. CONCLUSION: Hyperfractionated stereotactic re-RT is a reasonable treatment option for patients with recurrent/second primary HNSCC who were previously exposed to high-dose irradiation and who are not candidates for systemic treatment or hypofractionation.
Department of Maxilofacial Surgery University Hospital Ostrava Ostrava Czech Republic
Department of Oncology University Hospital Ostrava listopadu 1790 708 52 Ostrava Czech Republic
Department of Otolaryngology University Hospital Ostrava Ostrava Czech Republic
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