New, improved methods to access nucleosides are of general interest not only to organic chemists but to the greater scientific community as a whole due their key implications in life and disease. Current synthetic methods involve multistep procedures employing protected sugars in the glycosylation of nucleobases. Using modified Mitsunobu conditions, we report on the first direct glycosylation of purine and pyrimidine nucleobases with unprotected D-ribose to provide β-pyranosyl nucleosides and a one-pot strategy to yield β-furanosides from the heterocycle and 5-O-monoprotected D-ribose.

Department of Organic Chemistry Faculty of Science Charles University Prague Hlavova 8 Prague 2 12843 Czech Republic

Institute of Chemistry Humboldt Universität zu Berlin Brook Taylor Strasse 2 Berlin 12489 Germany

Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic Gilead and IOCB Research Center Flemingovo nám 2 Prague 6 16610 Czech Republic

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