VIM-39, a VIM-1-like metallo-β-lactamase variant (VIM-1 Thr33Ala His224Leu) was identified in a clinical isolate of Klebsiella pneumoniae belonging to sequence type 147. VIM-39 hydrolyzed ampicillin, cephalothin, and imipenem more efficiently than did VIM-1 and VIM-26 (a VIM-1 variant with the His224Leu substitution) because of higher turnover rates.

Department of Medical Biotechnologies University of Siena Siena Italy

Department of Medical Biotechnologies University of Siena Siena Italy Department of Experimental and Clinical Medicine University of Florence Florence Italy Clinical Microbiology and Virology Unit Careggi University Hospital Florence Italy

Faculty of Medicine and University Hospital in Plzen Charles University Prague Plzen Czech Republic Biomedical Center Faculty of Medicine in Plzen Charles University Prague Plzen Czech Republic

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