Antiplatelet Effects of Flavonoids Mediated by Inhibition of Arachidonic Acid Based Pathway
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cyclooxygenase 1 metabolism MeSH
- Flavonoids chemistry pharmacology MeSH
- Platelet Aggregation Inhibitors chemistry pharmacology MeSH
- Cyclooxygenase Inhibitors pharmacology MeSH
- Arachidonic Acid antagonists & inhibitors metabolism MeSH
- Humans MeSH
- Receptors, Thromboxane antagonists & inhibitors MeSH
- Thromboxane-A Synthase antagonists & inhibitors MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cyclooxygenase 1 MeSH
- Flavonoids MeSH
- Platelet Aggregation Inhibitors MeSH
- Cyclooxygenase Inhibitors MeSH
- Arachidonic Acid MeSH
- Receptors, Thromboxane MeSH
- Thromboxane-A Synthase MeSH
Flavonoids, important components of human diet, have been claimed to possess a significant antiplatelet potential, in particular due to their effects on the arachidonic acid cascade. Due to variable and incomplete results, this study was aimed at delivering a detailed analysis of the effects of 29 structurally relevant, mainly natural flavonoids on three consecutive steps of the arachidonic acid cascade.Only the isoflavonoids genistein and daidzein were shown to possess a marked cyclooxygenase-1 inhibitory activity, which was higher than that of acetylsalicylic acid using the isolated ovine enzyme, and physiologically relevant, although lower than acetylsalicylic acid in human platelets. None of the tested flavonoids possesses an effect on thromboxane synthase in a clinically achievable concentration. Contrarily, many flavonoids, particularly those possessing an isolated 7-hydroxyl group and/or a 4'-hydroxyl group, acted as antagonists on thromboxane receptors. Interestingly, the substitution of the free 7-hydroxyl group by glucose might not abolish the activity.In conclusion, the consumption of few flavonoids in a diet, particularly of the isoflavonoids genistein and daidzein, may positively influence platelet aggregation.
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