Kinetic analysis of decreased sperm fertilizing ability by fluorides and fluoroaluminates: a tool for analyzing the effect of environmental substances on biological events
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26394782
DOI
10.1007/s00249-015-1078-x
PII: 10.1007/s00249-015-1078-x
Knihovny.cz E-zdroje
- Klíčová slova
- Acrosome reaction, Capacitation, Fluoride complexes, Kinetics, Sperm fertilizing ability, Tyrosine phosphorylation,
- MeSH
- akrozomální reakce * MeSH
- fluor škodlivé účinky farmakologie MeSH
- fluoridy škodlivé účinky farmakologie MeSH
- hliník škodlivé účinky farmakologie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- spermie cytologie účinky léků fyziologie MeSH
- zrání spermie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- fluor MeSH
- fluoridy MeSH
- fluoroaluminum MeSH Prohlížeč
- hliník MeSH
Fluorides and fluoroaluminates decrease mouse sperm fertilizing potential by modifying the process of sperm preparation for fertilization, so-called capacitation, followed by acrosome reaction (AR). Capacitation was monitored by protein tyrosine phosphorylation (pTyr), and AR was induced consequently. The aim of this study was to apply kinetic analysis to the previously obtained dependences of pTyr and AR at capacitation times, and propose a mathematical theory for a mechanism when sperm maturation ability is amended by external stimuli. The experimental input data, previously obtained, are consistent with the proposed theory and the results of kinetic analysis show that sperm capacitation runs as two subsequent first-order steps. Firstly, an unstable intermediate is formed and then gradually decomposes. The time corresponding to the maximal production of the unstable intermediate is probably most suitable for sperm obtaining the ability to fertilize the egg. The presented calculations indicate that the application of kinetic analysis can serve as a tool to predict or confirm a course of biological events that are modified by external factors, and therefore the proposed theory shall be of interest to a broad scientific audience.
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