TOPICAL CORTICOSTEROIDS BUT NOT CALCINEURIN INHIBITORS INDUCED ATROPHY AFTER FOUR WEEKS
Language English Country Singapore Media print
Document type Clinical Trial, Comparative Study, Letter, Research Support, Non-U.S. Gov't
PubMed
26403410
PII: 21
Knihovny.cz E-resources
- MeSH
- Anti-Inflammatory Agents administration & dosage MeSH
- Administration, Topical MeSH
- Dermatitis, Atopic drug therapy metabolism pathology MeSH
- Time Factors MeSH
- Child MeSH
- Adult MeSH
- Calcineurin Inhibitors administration & dosage MeSH
- Middle Aged MeSH
- Humans MeSH
- Methylprednisolone administration & dosage analogs & derivatives MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Aged MeSH
- Tacrolimus administration & dosage MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Letter MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Inflammatory Agents MeSH
- Calcineurin Inhibitors MeSH
- Methylprednisolone MeSH
- methylprednisolone aceponate MeSH Browser
- Tacrolimus MeSH
Reflectance confocal microscopy (RCM) is a non-invasive, in vivo technique for real-time imaging of the epidermis and superficial dermis at the cellular resolution. We performed a pilot study focusing on the evaluation of the effect of topical corticosteroids and calcineurin inhibitors on the epidermis of patients with atopic dermatitis (AD). The effect was assessed by RCM. A total of 45 patients with AD took part in the study. Patients were selected according to the standardized protocol and divided into two groups. Twenty-three patients used methylprednisolone aceponat topically on the skin with lesions of AD once a day for three months (group A). Twenty-one patients applied topical tacrolimus on the skin with lesions of AD twice a day for three months (B). RCM imaging was performed on the day of intiating the study (T0), then after one (T1), two (T2) and three months (T3). In group A, there was a visible decrease of the stratum corneum and the epidermis thickness which was statistically significant. In comparison, in group B, such changes were not noted and the differences between the groups in time course were statistically significant. In group A, an increase in the percentage of blurred keratinocytes in the stratum spinosum was also recorded, especially between the first (T0) and the second visit (T1). RCM is a useful method for evaluating the changes in epidermis due to the different topical treatment in patients with AD.
Department of Biostatistics National Institute of Public Health Prague Czech Republic
Department of Dermatology and Venereology of the University of Guglielmo Marconi Rome Italy
Department of Dermatology University of Modena and Reggio Emilia Modena Italy
Department of Epidemiology 2nd Faculty of Medicine Charles University Prague Czech Republic
