CD (cluster of differentiation) Ags are cell surface molecules expressed on leukocytes and other cells relevant for the immune system. CD nomenclature has been universally adopted by the scientific community and is officially approved by the International Union of Immunological Societies and sanctioned by the World Health Organization. It provides a unified designation system for mAbs, as well as for the cell surface molecules that they recognize. This nomenclature was established by the Human Leukocyte Differentiation Antigens Workshops. In addition to defining the CD nomenclature, these workshops have been instrumental in identifying and determining the expression and function of cell surface molecules. Over the past 30 y, the data generated by the 10 Human Leukocyte Differentiation Antigens Workshops have led to the characterization and formal designation of more than 400 molecules. CD molecules are commonly used as cell markers, allowing the identification and isolation of leukocyte populations, subsets, and differentiation stages. mAbs against these molecules have proven to be essential for biomedical research and diagnosis, as well as in biotechnology. More recently, they have been recognized as invaluable tools for the treatment of several malignancies and autoimmune diseases. In this article, we describe how the CD nomenclature was established, present the official updated list of CD molecules, and provide a rationale for their usefulness in the 21st century.

BD Biosciences San Jose CA 95131;

Child Health Research Institute and University of Adelaide Adelaide 5000 Australia; and

Clinical and Experimental Onco Hematology Unit Oncological Referral Center Aviano 33081 Italy;

Dendritic Cell Research Australian and New Zealand Army Corps Research Institute University of Sydney Sydney 2139 Australia

Department of Immunology Central Clinical School Monash University Melbourne Victoria 3004 Australia;

Department of Immunology The 4th Military Medical University Xi'an 710032 China;

Immunology Unit Department of Cell Biology Immunology and Neurosciences Medical School University of Barcelona Barcelona 08036 Spain;

INSERM Paris 75014 France;

INSERM U976 Hospital Saint Louis University of Paris Paris 75010 France;

Institute for Hygiene and Applied Immunology Centre for Pathophysiology Infectiology and Immunology Medical University of Vienna Vienna 1090 Austria;

Institute of Molecular Genetics Czech Academy of Sciences Prague 142 20 Czech Republic;

Laboratory of Immunogenetics and Center for Experimental Research and Medical Studies Department of Medical Sciences University of Turin Turin 10126 Italy;

R and D Systems Bio Techne Corporation Minneapolis MN 55413;

Tumor Immunology Program German Cancer Research Center Heidelberg 69120 Germany;

Citace poskytuje Crossref.org

Standardization of Workflow and Flow Cytometry Panels for Quantitative Expression Profiling of Surface Antigens on Blood Leukocyte Subsets: An HCDM CDMaps Initiative

CD Maps-Dynamic Profiling of CD1-CD100 Surface Expression on Human Leukocyte and Lymphocyte Subsets