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PubMed

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Thiotepa-based high-dose therapy for autologous stem cell transplantation in lymphoma: a retrospective study from the EBMT

Sellner, L
Author Sellner, L Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany
Boumendil, A
Author Boumendil, A Lymphoma Working Party, European Society for Blood and Marrow Transplantation, Paris, France
Finel, H
Author Finel, H Lymphoma Working Party, European Society for Blood and Marrow Transplantation, Paris, France
Choquet, S
Author Choquet, S Department of Hematology, Pitié-Salpêtrière Hospital, Paris, France
de Rosa, G
Author de Rosa, G University of Napoli, Napoli, Italy
Falzetti, F
Author Falzetti, F University of Perugia, Perugia, Italy
Scime, R
Author Scime, R Department of Hematology, Azienda Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
Kobbe, G
Author Kobbe, G University Hospital Düsseldorf, Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Düsseldorf, Germany
Ferrara, F
Author Ferrara, F Cardarelli Hospital, Napoli, Italy
Delmer, A
Author Delmer, A Service d'Hématologie Clinique, Hôpital Robert Debré, Centre Hospitalier Universitaire (CHU) de Reims, Reims, France
Sayer, H
Author Sayer, H Department of Hematology and Oncology, Helios Hospital Erfurt, Erfurt, Germany
Amorim, S
Author Amorim, S APHP, Hopital Saint-louis, Hemato-Oncology Paris Diderot University, Sorbonne Paris Cité, Paris, France
Bouabdallah, R
Author Bouabdallah, R Hematology Department, Paoli Calmettes Institute, Marseille Aix-Marseille University, Marseille, France
Finke, J
Author Finke, J Department of Hematology, Freiburg University Medical Center, Freiburg, Germany
Salles, G
Author Salles, G Hematologie, Hospices Civils de Lyon and Université Claude Bernard Lyon-1, Pierre Bénite, France
Yakoub-Agha, I
Author Yakoub-Agha, I LIRIC-U995, Hematology Department and Hematopoietic Stem Cell Transplantation Unit, University-Hospital of Lille, Lille, France
Faber, E
Author Faber, E Department of Hemato-Oncology, Faculty Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
Nicolas-Virelizier, E
Author Nicolas-Virelizier, E Hematology Department, Centre Leon Berard, Lyon, France
Facchini, L
Author Facchini, L Hematology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Vallisa, D
Author Vallisa, D Hematology Unit, Ospedale Civile, Piacenza, Italy
Zuffa, E
Author Zuffa, E Hematology Unit, S Maria delle Croci Hospital, Ravenna, Italy
Sureda, A
Author Sureda, A Lymphoma Working Party, European Society for Blood and Marrow Transplantation, Paris, France Institut Català d'Oncologia, Hospital Duran i Reynals, Barcelona, Spain
Dreger, P
Author Dreger, P Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany Lymphoma Working Party, European Society for Blood and Marrow Transplantation, Paris, France
EBMT Lymphoma Working Party
Author EBMT Lymphoma Working Party

Bone marrow transplantation. 2016 Feb ; 51 (2) : 212-218. [epub] 20151116

Bone Marrow Transplant
ISSN 1476-5365 | 0268-3369
Source

Language English Country Great Britain, England Media print-electronic

Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid26569093

PubMed 26569093
DOI 10.1038/bmt.2015.273
PII: bmt2015273
Knihovny.cz E-resources

MeSH
Autografts MeSH
Cytarabine administration & dosage MeSH
Adult MeSH
Carmustine administration & dosage MeSH
Middle Aged MeSH
Humans MeSH
Lymphoma mortality therapy MeSH
Melphalan administration & dosage MeSH
Survival Rate MeSH
Adolescent MeSH
Podophyllotoxin administration & dosage MeSH
Disease-Free Survival MeSH
Antineoplastic Combined Chemotherapy Protocols administration & dosage MeSH
Registries * MeSH
Retrospective Studies MeSH
Aged MeSH
Thiotepa administration & dosage MeSH
Stem Cell Transplantation * MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Adolescent MeSH
Male MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Multicenter Study MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
Cytarabine MeSH
Carmustine MeSH
Melphalan MeSH
Podophyllotoxin MeSH
Thiotepa MeSH

Clinical information about thiotepa-based autologous stem cell transplantation (auto-SCT) outside the primary central nervous system lymphoma (PCNSL) field is sparse. In this registry-based retrospective study, we evaluated potential risks and benefits of thiotepa-based preparative regimens compared with BEAM (carmustine, etoposide, cytarabine, melphalan) in auto-SCT for diffuse large B-cell lymphoma (DLBCL, excluding PCNSL), follicular lymphoma (FL) or Hodgkin lymphoma (HL). A total of 14 544 patients (589 thiotepa and 13 955 BEAM) met the eligibility criteria, and 535 thiotepa- and 1031 BEAM-treated patients were matched in a 1:2 ratio for final comparison. No significant differences between thiotepa and BEAM groups for any survival end point were identified in the whole sample or disease entity subsets. For a more detailed analysis, 47 TEAM (thiotepa, etoposide, cytarabine, melphalan)-treated patients were compared with 75 matched BEAM patients with additional collection of toxicity data. Again, there were no significant differences between the two groups for any survival end point. In addition, the frequency of common infectious and non-infectious complications including secondary malignancies was comparable between TEAM and BEAM. These results indicate that thiotepa-based high-dose therapy might be a valuable alternative to BEAM in DLBCL, HL and FL. Further evaluation by prospective clinical trials is warranted.

APHP Hopital Saint louis Hemato Oncology Paris Diderot University Sorbonne Paris Cité Paris France

Cardarelli Hospital Napoli Italy

Department of Hemato Oncology Faculty Hospital Olomouc and Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic

Department of Hematology and Oncology Helios Hospital Erfurt Erfurt Germany

Department of Hematology Azienda Ospedali Riuniti Villa Sofia Cervello Palermo Italy

Department of Hematology Freiburg University Medical Center Freiburg Germany

Department of Hematology Pitié Salpêtrière Hospital Paris France

Department of Medicine 5 University Hospital Heidelberg Heidelberg Germany

Hematologie Hospices Civils de Lyon and Université Claude Bernard Lyon 1 Pierre Bénite France

Hematology Department Centre Leon Berard Lyon France

Hematology Department Paoli Calmettes Institute Marseille Aix Marseille University Marseille France

Hematology Unit Arcispedale S Maria Nuova IRCCS Reggio Emilia Italy