Centrosome amplification and clonal evolution in multiple myeloma: Short review
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26589397
DOI
10.1016/j.critrevonc.2015.10.019
PII: S1040-8428(15)30068-8
Knihovny.cz E-resources
- Keywords
- Centrosome amplification, Clonal diversification, Multiple myeloma, Proliferation,
- MeSH
- Apoptosis physiology MeSH
- Clone Cells MeSH
- Centrosome pathology MeSH
- Stress, Physiological physiology MeSH
- Carcinogenesis pathology MeSH
- Clonal Evolution physiology MeSH
- Humans MeSH
- Multiple Myeloma genetics pathology MeSH
- Disease Progression MeSH
- Cell Proliferation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Multiple myeloma (MM) is composed of an array of multiple clones, each potentially associated with different clinical behavior. Previous studies focused on clinical implication of centrosome amplification (CA) in MM show contradictory results. It seems that the role of CA as well as CA formation in MM differ from other malignancies. This has brought about a question about the role of CA positive clone which is--is it going to be a more aggressive clone evolutionally arising under pressure of negative conditions or can CA serve as a marker of cell abnormality and lead to cell death and further elimination of this damaged subpopulation? This current review is devoted to the discussion of the existence of MM subclones with centrosome amplification (CA), its evolutionary behaviour within intraclonal heterogeneity as well as its potential impact on the disease progression and MM treatment.
References provided by Crossref.org
Centrosome associated genes pattern for risk sub-stratification in multiple myeloma
