Difference in white matter microstructure in differential diagnosis of normal pressure hydrocephalus and Alzheimer's disease
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26646649
DOI
10.1016/j.clineuro.2015.11.010
PII: S0303-8467(15)30076-7
Knihovny.cz E-resources
- Keywords
- Alzheimer's disease, DTI, MRI, Normal pressure hydrocephalus, TBSS, White matter,
- MeSH
- Alzheimer Disease diagnosis pathology MeSH
- Anisotropy MeSH
- White Matter pathology MeSH
- Diagnosis, Differential * MeSH
- Middle Aged MeSH
- Humans MeSH
- Hydrocephalus, Normal Pressure diagnosis pathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Diffusion Tensor Imaging methods MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVES: Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) are both associated with cognitive decline and ventriculomegaly. While promising approach in differentiating between the two diseases, only a few diffusion tensor imaging (DTI) studies compared directly NPH and AD patients. The current study compares global whitematter (WM) alterations in AD and NPH addressing some of the methodological issues of previous studies. PATIENTS AND METHODS: Diffusion tensor images were obtained from 17 patients with NPH, 14 with AD, and 17 healthy controls. White matter integrity was quantified by fractional anisotropy (FA), mean (MD), axial (λ1) and radial diffusivity (RD). The diffusion parameters were compared between the groups in 'skeletonised' tracts representing the core of the fibre bundles. RESULTS: Reduced FA was found in NPH patients throughout the corpus callosum, particularly in the splenium, along with increased RD. On the other hand, FA, MD and RD were higher in NPH in the cortico-fugal fibres arising from the frontal and parietal cortex. While no FA changes were detected in AD patients compared to controls, widespread increased RD was observed. When comparing NPH and AD patients, higher FA, MD and RD was observed in the corona radiata in the periventricular fibres arising from the frontal and parietal cortex in NPH patients. The ventricular volumes were correlated with diffusivity parameters in the tracts next to the ventricles in AD and NPH patients. CONCLUSION: Our analysis identified a pattern of WM diffusion alterations that can differentiate NPH patients from controls and AD patients.
Department of Neurology Faculty of General Medicine University of Szeged Szeged Hungary
Department of Neurosurgery University Hospital of Marburg Germany
Department of Radiodiagnostics University Central Military Hospital Prague Czech Republic
Department of Radiology Mayo Clinic Rochester MN USA
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
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