Use of electrogastrography in preclinical studies of cholinergic and anticholinergic agents in experimental pigs
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26674291
DOI
10.33549/physiolres.933227
PII: 933227
Knihovny.cz E-resources
- MeSH
- Muscarinic Antagonists pharmacology MeSH
- Atropine pharmacology MeSH
- Time Factors MeSH
- Cholinesterase Inhibitors pharmacology MeSH
- Electrodiagnosis MeSH
- Myoelectric Complex, Migrating drug effects MeSH
- Models, Animal MeSH
- Neostigmine pharmacology MeSH
- Swine MeSH
- Stomach drug effects MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Muscarinic Antagonists MeSH
- Atropine MeSH
- Cholinesterase Inhibitors MeSH
- Neostigmine MeSH
Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. The purpose of this study was to evaluate the effect of atropine and neostigmine on the EGG in experimental pigs. Adult female pigs were administrated atropine (1.5 mg i.m., n=6) and neostigmine (0.5 mg i.m., n=6) after the baseline EGG, followed by a 90-min trial recording (MMS, Enschede, the Netherlands). Running spectral analysis was used for the evaluation. The results were expressed as dominant frequency of slow waves and EGG power (areas of amplitudes). Neostigmine increased continuously the dominant frequency and decreased significantly the EGG power. Atropine did not change the dominant frequency significantly. However, atropine increased significantly the EGG power (areas of amplitudes) from basal values to the maximum at the 10-20-min interval. After that period, the areas of amplitudes decreased significantly to the lowest values at the 60-90-min interval. In conclusion, cholinergic and anticholinergic agents affect differently EGG in experimental pigs.
References provided by Crossref.org
