The steroid metabolome in men with mood and anxiety disorders
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26680490
DOI
10.33549/physiolres.933067
PII: 933067
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Metabolome physiology MeSH
- Adolescent MeSH
- Young Adult MeSH
- Neurotransmitter Agents blood MeSH
- Mood Disorders blood diagnosis MeSH
- Anxiety Disorders blood diagnosis MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Neurotransmitter Agents MeSH
The mood and behavior of individuals result from an orchestra of many factors. Among them steroids play an important role; however, only several common hormones have been investigated in this respect. It has been demonstrated that some steroid metabolites long considered merely the products of steroid hormone metabolism in fact possess considerable activity in the CNS. For this reason we studied the steroid metabolome including 50 analytes in 20 men with depression, 20 men with anxiety and 30 healthy controls. Significant differences were found not only between controls and men with either depression or anxiety, but also between men with depression and anxiety. Particularly striking were those steroids until now not generally associated with depression or anxiety, namely conjugated steroid forms, especially sulfates.
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