Treatment of hypertriglyceridemia: a review of current options
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26680666
DOI
10.33549/physiolres.933199
PII: 933199
Knihovny.cz E-resources
- MeSH
- Risk Reduction Behavior * MeSH
- Hypertriglyceridemia blood therapy MeSH
- Hypolipidemic Agents therapeutic use MeSH
- Humans MeSH
- Niacin therapeutic use MeSH
- Fatty Acids, Omega-3 therapeutic use MeSH
- Randomized Controlled Trials as Topic methods MeSH
- Risk Factors MeSH
- Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use MeSH
- Triglycerides blood MeSH
- Treatment Outcome MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Hypolipidemic Agents MeSH
- Niacin MeSH
- Fatty Acids, Omega-3 MeSH
- Hydroxymethylglutaryl-CoA Reductase Inhibitors MeSH
- Triglycerides MeSH
Hypertriglyceridemia is an important marker of increased levels of highly atherogenic remnant-like particles. The importance of lowering plasma levels of triglycerides (TG) has been called into question many times, but currently it is considered an integral part of residual cardiovascular risk reduction strategies. Lifestyle changes (improved diet and increased physical activity) are effective TG lowering measures. Pharmacological treatment usually starts with statins, although associated TG reductions are typically modest. Fibrates are currently the drugs of choice for hyperTG, frequently in combination with statins. Niacin and omega-3 fatty acids improve control of triglyceride levels when the above measures are inadequately effective. Some novel therapies including anti-sense oligonucleotides and inhibitors of microsomal triglyceride transfer protein have shown significant TG lowering efficacy. The current approach to the management of hypertriglyceridemia is based on lifestyle changes and, usually, drug combinations (statin and fibrate and/or omega-3 fatty acids or niacin).
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