Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
26768618
DOI
10.1007/s13277-016-4820-9
PII: 10.1007/s13277-016-4820-9
Knihovny.cz E-zdroje
- Klíčová slova
- Childhood cancer, Gene, Overall survival, SNP, VDR, Vitamin D,
- MeSH
- alely MeSH
- dítě MeSH
- frekvence genu genetika MeSH
- genetická predispozice k nemoci genetika MeSH
- genetické asociační studie metody MeSH
- genotyp MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé MeSH
- mladiství MeSH
- nádory genetika MeSH
- pilotní projekty MeSH
- předškolní dítě MeSH
- receptory kalcitriolu genetika MeSH
- vitamin D krev MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- receptory kalcitriolu MeSH
- vitamin D MeSH
Recently, vitamin D has been recognized as an important player in the immune system, and multiple studies suggested its involvement in cancer, too. The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570; C > T), TaqI (rs731236; T > C), ApaI (rs 7975232; C > T) and Cdx-2 (rs11568820; A > G), and to evaluate their possible predictive role for outcomes in patients with paediatric solid tumours. A total of 111 children with paediatric solid tumours were enrolled at the Department of Paediatric Oncology, University Hospital Brno (Brno, Czech Republic) along with a control population of 787 adults; all study subjects were available for genotyping of selected SNPs, and the prediagnostic levels of 25-hydroxycholecalciferol (25(OH)D3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in the cases, too. In FokI, the heterozygote CT genotype was weakly associated with a decreased risk of paediatric solid cancer occurrence 0.82 (0.53-1.28), while the CC genotype was associated with a decreased risk of 0.58 (0.30-1.09), p = 0.09. The 1,25(OH)2D3 prediagnostic levels were indicative of the overall survival in the cases (β = -0.012, HR 0.988, 95 % CI (0.978-0.998), while higher prediagnostic levels of 1,25(OH)2D3 were associated with a statistically significant increase in overall mortality. We observed multiple effects of the alleles of the investigated polymorphisms and of 1,25(OH)2D3 on overall survival, regardless of the underlying disease.
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J Pediatr Nurs. 2003 Apr;18(2):96-102 PubMed
Pediatr Blood Cancer. 2013 Jun;60(6):949-52 PubMed
Biochem Pharmacol. 2010 Jan 1;79(1):1-9 PubMed
Biomed Res Int. 2015;2015:625981 PubMed
Biochem J. 2000 Dec 1;352 Pt 2:301-9 PubMed
J Clin Oncol. 2010 May 20;28(15):2625-34 PubMed
Tumour Biol. 2015 Jun;36(6):4707-14 PubMed
Acta Diabetol. 2011 Dec;48(4):329-336 PubMed
Oncologist. 2012;17(1):36-45 PubMed
BMC Cancer. 2010 Jul 02;10:347 PubMed
J Clin Endocrinol Metab. 1999 Sep;84(9):3174-81 PubMed
Mol Endocrinol. 2000 Mar;14(3):401-20 PubMed
Oncogene. 2015 Oct 8;34(41):5207-15 PubMed
J Pediatr Hematol Oncol. 2003 Oct;25(10):780-6 PubMed
Trends Neurosci. 2012 Sep;35(9):565-73 PubMed
Adv Exp Med Biol. 2014;810:33-51 PubMed
PLoS One. 2013;8(3):e57967 PubMed
Mult Scler. 2009 May;15(5):563-70 PubMed
J Clin Oncol. 2008 Jun 20;26(18):2984-91 PubMed
Nutr Rev. 2007 Aug;65(8 Pt 2):S102-4 PubMed
Endocrinol Metab Clin North Am. 2010 Jun;39(2):255-69, table of contents PubMed
Clin Biochem Rev. 2015 May;36(2):53-61 PubMed
Adv Exp Med Biol. 2008;624:31-42 PubMed
