Recent studies reported the critical role of the intrauterine environment of a fetus in growth or the development of disease in adulthood. In this article we discussed the implications of salt restriction in growth of a fetus and the development of growth-related disease in adulthood. Salt restriction causes retardation of fatal growth or intrauterine death thereby leading to low birth weight or decreased birth rate. Such retardation of growth along with the upregulation of the renin angiotensin system due to salt restriction results in the underdevelopment of cardiovascular organs or decreases the number of the nephron in the kidney and is responsible for onset of hypertension in adulthood. In addition, gestational salt restriction is associated with salt craving after weaning. Moreover, salt restriction is associated with a decrease in insulin sensitivity. A series of alterations in metabolism due to salt restriction are probably mediated by the upregulation of the renin angiotensin system and an epigenetic mechanism including proinflammatory substances or histone methylation. Part of the metabolic disease in adulthood may be programmed through such epigenetic changes. The modification of gene in a fetus may be switched on through environment factors or life style after birth. The benefits of salt restriction have been assumed thus far; however, more precise investigation is required of its influence on the health of fetuses and the onset of various diseases in adulthood.

2nd Department of Internal Medicine Faculty of Medicine Masaryk University Pekarska 53 656 91 Brno Czech Republic

Division of Clinical Nutrition Faculty of Home Economics Kyoritsu Women's University 2 2 1 Hitotsubashi Chiyoda Tokyo 101 8437 Japan

Laboratory of Structural Biology and Proteomics Central Laboratories Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Brno Czech Republic

The Centre for Chronic Disease Prevention and Management Western CHRE Victoria University St Albans Australia

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