DNA, the central molecule of aging
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26871429
DOI
10.1016/j.mrfmmm.2016.01.007
PII: S0027-5107(16)30007-0
Knihovny.cz E-resources
- Keywords
- Aging, Chromatin structure, DNA, DNA damage, DNA repair, Mutagenesis, Telomeres,
- MeSH
- Chromatin ultrastructure MeSH
- DNA chemistry genetics MeSH
- Humans MeSH
- DNA Repair physiology MeSH
- DNA Damage physiology MeSH
- Aging genetics MeSH
- Telomere Shortening MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Chromatin MeSH
- DNA MeSH
Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes.
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